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Changing Medicine Together!
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Arthritis,
~ Autoimmune Disorders ~
Gout, Lupus
Patent:
US6410588B1 1998-04-14 2002-06-25 Anti-inflammatory Agent: The Mathilda And Terence Kennedy Institute Of Rheumatology Use of cannabinoids as anti-inflammatory agents
US6630507 Autoimmune Disorders; Cannabiniods as antioxidants & neuroprotectants (eg Rheumatism Arthritis)
US6630507 Autoimmune Disorders; Cannabiniods as antioxidants & neuroprotectants (eg Rheumatism Arthritis)
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Note: Autoimmune Disorder, is responsible for over 100 diseases, from rheumatoid arthritis, lupus, type 1 diabetes, celiac, psoriasis, multiple sclerosis & on. There is clearly a link (hence the summarized title, Autoimmune) although the clear differences, eg. Arthritis, Lupus. This aspect makes it difficult for big Pharma to Band-Aid the problem.
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Cannabis is very beneficial in all cases, as the Endocannabiniod System regulates all major organs and functioning bodily systems, eg. Immune, Nervous, Digestive, Lymph, etc. It Promotes Homeostasis throughout the body.
Cannabis has Regenerative functionalities ( in cells, neurons, muscle, vitamins, minerals, bone, etc), Assists in vitamin transport, enhancement, & synthesis, cannabis Activates the appropriate proteins & enzymes the body requires, all the while supressing the harmful proteins & enzymes, it Produces H2O2 which produces oxygen, and even decalcifies/plaque dissolving. With all these properties & |
much more, with no adverse side affects Cannabis is clearly the safe and beneficial treatment.
Preferred Strains
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Pennywise
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THC 0.0/14.0%
CBD 0.0/23.4% CBN 0.0/0.O7% THC/CBD Ratio 1:2 Indica dominant |
THC 4.0/7.0%
CBD 8.0/16.0% CBN0.0/0.02% THC/CBD Ratio 2:5 75/25% Sativa Dominant |
THC 8.0/16.0%
CBD 8.0/16.0% CBN 0.10/0.13% THC/CBD Ratio 1:1 70/30% Indica Dominant |
THC 0.42/1.20%
CBD 16.0/24.0% CBN 0.0/0.20% THC/CBD Ratio 1:20 |
Preferred Methods to medicate
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Important Note:
In 2013, researchers discovered something interesting about Rheumatoid arthritis. Cells taken from RA patients had more CB2 receptors in their immune cells.
In a sense, the increased number of receptor sites is a sign that the cells are calling out for more endocannabinoids.
For some reason, the cells need an increased amount of endocannabinoid stimulation to function properly.
In 2013, researchers discovered something interesting about Rheumatoid arthritis. Cells taken from RA patients had more CB2 receptors in their immune cells.
In a sense, the increased number of receptor sites is a sign that the cells are calling out for more endocannabinoids.
For some reason, the cells need an increased amount of endocannabinoid stimulation to function properly.
About Arthritis
Arthritis is a term often used to mean any disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. In some types other organs are also affected. Onset can be gradual or sudden.
There are over 100 types of arthritis. The most common forms are osteoarthritis (degenerative joint disease) and rheumatoid arthritis. Osteoarthritis usually occurs with age and affects the fingers, knees, and hips. Rheumatoid arthritis is an autoimmune disease that often affects the hands and feet. Other types include gout, lupus, fibromyalgia, and septic arthritis. They are all types of rheumatic disease. Treatment may include resting the joint and alternating between applying ice and heat. Weight loss and exercise may also be useful. Pain medications such as ibuprofen and paracetamol (acetaminophen) may be used. In some a joint replacement may be useful.
Osteoarthritis affects more than 3.8% of people while rheumatoid arthritis affects about 0.24% of people. Gout affects about 1 to 2% of the Western population at some point in their lives. In Australia about 15% of people are affected, while in the United States more than 20% have a type of arthritis. Overall the disease becomes more common with age. Arthritis is a common reason that people miss work and can result in a decreased quality of life. The term is from Greek arthro- meaning joint and -it is meaning Inflammation.
Although there is a difference in the manner, in which the inflammation is able to progress into Arthritis, Ultimately inflammation is a process i which the body has or thinks something is wrong and send a message to that particular area to inflame for protection, ( Isolating the problem, as to not spread.) Therefore the medicinal properties of cannabis in relation to inflammation will help regardless of Arthritis type. Cannabis blocks/surpresses inflammatory proteins and activates Anti-inflammatory proteins. more on cannabis & arthritis below.
There are over 100 types of arthritis. The most common forms are osteoarthritis (degenerative joint disease) and rheumatoid arthritis. Osteoarthritis usually occurs with age and affects the fingers, knees, and hips. Rheumatoid arthritis is an autoimmune disease that often affects the hands and feet. Other types include gout, lupus, fibromyalgia, and septic arthritis. They are all types of rheumatic disease. Treatment may include resting the joint and alternating between applying ice and heat. Weight loss and exercise may also be useful. Pain medications such as ibuprofen and paracetamol (acetaminophen) may be used. In some a joint replacement may be useful.
Osteoarthritis affects more than 3.8% of people while rheumatoid arthritis affects about 0.24% of people. Gout affects about 1 to 2% of the Western population at some point in their lives. In Australia about 15% of people are affected, while in the United States more than 20% have a type of arthritis. Overall the disease becomes more common with age. Arthritis is a common reason that people miss work and can result in a decreased quality of life. The term is from Greek arthro- meaning joint and -it is meaning Inflammation.
Although there is a difference in the manner, in which the inflammation is able to progress into Arthritis, Ultimately inflammation is a process i which the body has or thinks something is wrong and send a message to that particular area to inflame for protection, ( Isolating the problem, as to not spread.) Therefore the medicinal properties of cannabis in relation to inflammation will help regardless of Arthritis type. Cannabis blocks/surpresses inflammatory proteins and activates Anti-inflammatory proteins. more on cannabis & arthritis below.
Classifications
There are several diseases where joint pain is primary, and is considered the main feature. Generally when a person has "arthritis" it means that they have one of these diseases, which include:
- Osteoarthritis
- Rheumatoid arthritis
- Gout and pseudo-gout
- Septic arthritis
- Ankylosing spondylitis
- Juvenile idiopathic arthritis
- Still's disease
- Psoriasis (Psoriatic arthritis)
- Reactive arthritis
- Ehlers-Danlos Syndrome
- Haemochromatosis
- Hepatitis
- Lyme disease
- Sjogren's disease
- Hashimoto's thyroiditis
- Celiac disease
- Non-celiac gluten sensitivity
- Inflammatory bowel disease (including Crohn's disease and ulcerative colitis)
- Henoch–Schönlein purpura
- Hyperimmunoglobulinemia D with recurrent fever
- Sarcoidosis
- Whipple's disease
- TNF receptor associated periodic syndrome
- Granulomatosis with polyangiitis (and many other vasculitis syndromes)
- Familial Mediterranean fever
- Systemic lupus erythematosus
Diagnosis is made by clinical examination from an appropriate health professional, and may be supported by other tests such as radiology and blood tests, depending on the type of suspected arthritis. All arthritides potentially feature pain. Pain patterns may differ depending on the arthritides and the location. Rheumatoid arthritis is generally worse in the morning and associated with stiffness; in the early stages, patients often have no symptoms after a morning shower. Osteoarthritis, on the other hand, tends to be worse after exercise. In the aged and children, pain might not be the main presenting feature; the aged patient simply moves less, the infantile patient refuses to use the affected limb.
Elements of the history of the disorder guide diagnosis. Important features are speed and time of onset, pattern of joint involvement, symmetry of symptoms, early morning stiffness, tenderness, gelling or locking with inactivity, aggravating and relieving factors, and other systemic symptoms. Physical examination may confirm the diagnosis, or may indicate systemic disease. Radiographs are often used to follow progression or help assess severity.
Blood tests and X-rays of the affected joints often are performed to make the diagnosis. Screening blood tests are indicated if certain arthritides are suspected. These might include: rheumatoid factor, antinuclear factor (ANF), extractable nuclear antigen, and specific antibodies.
Elements of the history of the disorder guide diagnosis. Important features are speed and time of onset, pattern of joint involvement, symmetry of symptoms, early morning stiffness, tenderness, gelling or locking with inactivity, aggravating and relieving factors, and other systemic symptoms. Physical examination may confirm the diagnosis, or may indicate systemic disease. Radiographs are often used to follow progression or help assess severity.
Blood tests and X-rays of the affected joints often are performed to make the diagnosis. Screening blood tests are indicated if certain arthritides are suspected. These might include: rheumatoid factor, antinuclear factor (ANF), extractable nuclear antigen, and specific antibodies.
How Cannabis Aids
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Dr. Jason McDougall Cannabis & Arthritis
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Dr. McDougall, Science of Cannabis & Arthritis
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cannabis use among Seniors with Arthritis
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There are two cannabinoids found in marijuana that have especially profound efficacy for those with arthritis: CBD and THC. CBD, or cannabidiol, is responsible for immune system modulation, meaning it is helpful for an autoimmune condition like rheumatoid arthritis. THC, or tetrahydrocannabinol — and byproducts of its metabolism — has been found to be anti-inflammatory and analgesic (pain killing). THC is also known to reduce the anxiety and depression that commonly accompany severe diseases, especially those that affect one’s mobility.
Cannabis has several functions known to date that aid in helping inflammation, including indirectly, by regulating/creating homeostasis through the bodily systems.
Directly aiding by:
1- Research from 2014 made the groundbreaking discovery that cannabis:
modulates changes to specific molecules called histones. Histones help control gene expression. The research found that THC can cause changes to histones in a way that suppresses inflammation.
2 - Further, studies have shown that:
cannabinoids downregulate/supress certain inflammatory proteins called cytokines.
3 - They found that CBD treatment caused levels of pro-inflammatory cytokines to decrease, all the while levels of anti-inflammatory proteins increased.
4 - Cannabis activates T-regulatory cells, which prevent cells from attacking itself. eg.( Hyper active immune system).
5 - Cannabis promotes cell death in rogue cells.
The immune imbalance was tentatively corrected by Cannabis as the endocannabinoid system regulates the immune system.
Cannabis is such a powerful anti-inflammatory that it has been shown to aid in remission of Crohn’s Disease. Crohn’s is a bowel disease in which inflammation in the gut runs rampant.
The efficacy of cannabis for a wide variety of autoimmune and neurological conditions is the core focus of the medical marijuana movement. However, the sheer number of arthritis sufferers makes the development of new drugs or therapies targeted at this specific condition of special interest to a variety of companies. One example is Cannabis Technologies, a company based in Vancouver that is in the process of developing a new cannabinoid-based therapy that will directly treat arthritis.
In the summer of 2015, the Canadian Arthritis Society funded a three-year research grant to a Dalhousie University researcher to determine if marijuana can relieve pain or repair arthritic joints. Pain-detecting nerves are filled with cannabinoid receptors, and according to researcher Jason McDougall, cannabinoids control the firing of pain signals from the joint to the brain by sticking themselves to nerve receptors. Another controlled study, conducted by the Royal National Hospital for Rheumatic Disease in the UK, showed that cannabinoids provided statistically significant improvements in pain on movement, pain at rest, and quality of sleep.
At a time when opiate abuse has reached epidemic proportions, cannabis treatment can be a far less harmful and less addictive way to treat those suffering from chronic pain associated with arthritis. According to Mike Hart, MD, head physician of the Ontario Chapter at Marijuana for Trauma (MFT):
“Cannabis is much more effective and safer long term solution than opioids. The science is clear and demonstrates that cannabis is far safer than opioids. Opioids have killed more people than all illegal drugs combined, while cannabis has never killed a single person.”
Although sativa strains are usually credited for being better pain relievers, some indica strains can also provide relief from arthritis symptoms.
Cannabis has several functions known to date that aid in helping inflammation, including indirectly, by regulating/creating homeostasis through the bodily systems.
Directly aiding by:
1- Research from 2014 made the groundbreaking discovery that cannabis:
modulates changes to specific molecules called histones. Histones help control gene expression. The research found that THC can cause changes to histones in a way that suppresses inflammation.
2 - Further, studies have shown that:
cannabinoids downregulate/supress certain inflammatory proteins called cytokines.
3 - They found that CBD treatment caused levels of pro-inflammatory cytokines to decrease, all the while levels of anti-inflammatory proteins increased.
4 - Cannabis activates T-regulatory cells, which prevent cells from attacking itself. eg.( Hyper active immune system).
5 - Cannabis promotes cell death in rogue cells.
The immune imbalance was tentatively corrected by Cannabis as the endocannabinoid system regulates the immune system.
Cannabis is such a powerful anti-inflammatory that it has been shown to aid in remission of Crohn’s Disease. Crohn’s is a bowel disease in which inflammation in the gut runs rampant.
The efficacy of cannabis for a wide variety of autoimmune and neurological conditions is the core focus of the medical marijuana movement. However, the sheer number of arthritis sufferers makes the development of new drugs or therapies targeted at this specific condition of special interest to a variety of companies. One example is Cannabis Technologies, a company based in Vancouver that is in the process of developing a new cannabinoid-based therapy that will directly treat arthritis.
In the summer of 2015, the Canadian Arthritis Society funded a three-year research grant to a Dalhousie University researcher to determine if marijuana can relieve pain or repair arthritic joints. Pain-detecting nerves are filled with cannabinoid receptors, and according to researcher Jason McDougall, cannabinoids control the firing of pain signals from the joint to the brain by sticking themselves to nerve receptors. Another controlled study, conducted by the Royal National Hospital for Rheumatic Disease in the UK, showed that cannabinoids provided statistically significant improvements in pain on movement, pain at rest, and quality of sleep.
At a time when opiate abuse has reached epidemic proportions, cannabis treatment can be a far less harmful and less addictive way to treat those suffering from chronic pain associated with arthritis. According to Mike Hart, MD, head physician of the Ontario Chapter at Marijuana for Trauma (MFT):
“Cannabis is much more effective and safer long term solution than opioids. The science is clear and demonstrates that cannabis is far safer than opioids. Opioids have killed more people than all illegal drugs combined, while cannabis has never killed a single person.”
Although sativa strains are usually credited for being better pain relievers, some indica strains can also provide relief from arthritis symptoms.
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The Connection
Arthritis & Cannabis A break down, How Cannabis Aids |
Autoimmunity & Cannabis
How Cannabis Aids in Inflammation
How Cannabis Aids in Inflammation
ECBs in the immune system. In contrast to the drug war propaganda that cannabinoids are immunosuppressive, researchers have found that cannabinoids modulate the immune system, just as they modulate other bodily systems. The Immune system has a majority of CB 2 receptors on which it seems to utilize, although that's not to say that it does not utilize the CB 1 receptors as there about a 80/20 ratio. Cannabinoids have been shown to decrease Th1 cytokine levels, increase the levels of Th2 cytokines, and increase certain subsets of B, T, and NK (natural killer) cells. Phytocannabinoids also have other immune-mediating mechanisms that are separate from cannabinoid receptors. For example, THCa, the acidic form of THC, can inhibit the release of tumor necrosis factor-alpha from macrophages. finding are also showing the Immune System will send CB receptors or (signals for the cells to produce receptors) to areas of need, injury, inflammation or the need for homeostasis.
Bone & Joint deterioration & Cannabis
Cannabis Aiding in the prevention of Erosion & Stimulating Re-growth of bone, Cartilage, & Connective tissue
Cannabis Aiding in the prevention of Erosion & Stimulating Re-growth of bone, Cartilage, & Connective tissue
Endocannabinoids and connective tissue In bone, both osteoblasts and osteoclast produce anandamide and 2-AG, and both express the CB2 receptor. Stimulation of this receptor leads to decreased osteoclast activity and increased osteoblast activity, thus increasing bone formation. There are CB1 receptors on the sympathetic nerve terminals close to the osteoblasts. These nerves release norepinephrine, which restrains bone formation. Retrograde CB1 signaling will inhibit the release of the norepinephrine and alleviate this tonic sympathetic restraint, thus allowing bone to form. Cells in other connective tissues —fibroblasts, myofibroblasts, chondrocytes, and synoviocytes— express both CB1 and CB2 receptors, and the enzymes used to metabolize endocannabinoids. CB1 receptors have been found to be upregulated after exposure to inflammatory cytokines and equiaxial stretching of fibroblasts in models of stress. Cannabinoids also modulate fascia remodeling via fibroblast focal adhesions. Cannabinoids have been shown to prevent cartilage destruction by inhibiting chondrocyte expression of cytokines and metalloproteinase enzymes. Cannabinoids have also been shown to decrease connective tissue inflammation. Animal models of atherosclerosis demonstrate that CB2 receptor activation on macrophages within atherosclerotic plaques can decrease atherosclerosis
Osteoarthritis
Most Common: Osteoarthritis & Cannabis
Osteoarthritis is the most common form of arthritis. It can affect both the larger and the smaller joints of the body, including the hands, wrists, feet, back, hip, and knee. The disease is essentially inflammatory one acquired from daily wear and tear of the joint unlike rheumatoid Arthritis ( incorrect signaling from hyperactive immune ); however, osteoarthritis can also occur as a result of injury. In recent years, some joint or limb deformities, such as knock-knee or acetabular over coverage or dysplasia, have also been considered as a predisposing factor for knee or hip osteoarthritis. Osteoarthritis begins in the cartilage and eventually causes the two opposing bones to erode into each other. The condition starts with minor pain during physical activity, but soon the pain can be continuous and even occur while in a state of rest. The pain can be debilitating and prevent one from doing some activities. Osteoarthritis typically affects the weight-bearing joints, such as the back, knee and hip. Unlike rheumatoid arthritis, osteoarthritis is most commonly a disease of the elderly. More than 30 percent of women have some degree of osteoarthritis by age 65. Risk factors for osteoarthritis include prior joint trauma, obesity, and a sedentary lifestyle.
Cannabis Direct Benefits:
- Cannabis supresses the protein Cytokines,
- Promotes anti-inflammatory proteins including the "T" regulatory cells ( Protector proteins ).
- Cannabis Promotes regeneration, eg. neurogenesis (brain/nerve regrowth), cellular, & Bone regrowth.
Most Common: Osteoarthritis & Cannabis
Osteoarthritis is the most common form of arthritis. It can affect both the larger and the smaller joints of the body, including the hands, wrists, feet, back, hip, and knee. The disease is essentially inflammatory one acquired from daily wear and tear of the joint unlike rheumatoid Arthritis ( incorrect signaling from hyperactive immune ); however, osteoarthritis can also occur as a result of injury. In recent years, some joint or limb deformities, such as knock-knee or acetabular over coverage or dysplasia, have also been considered as a predisposing factor for knee or hip osteoarthritis. Osteoarthritis begins in the cartilage and eventually causes the two opposing bones to erode into each other. The condition starts with minor pain during physical activity, but soon the pain can be continuous and even occur while in a state of rest. The pain can be debilitating and prevent one from doing some activities. Osteoarthritis typically affects the weight-bearing joints, such as the back, knee and hip. Unlike rheumatoid arthritis, osteoarthritis is most commonly a disease of the elderly. More than 30 percent of women have some degree of osteoarthritis by age 65. Risk factors for osteoarthritis include prior joint trauma, obesity, and a sedentary lifestyle.
Cannabis Direct Benefits:
- Cannabis supresses the protein Cytokines,
- Promotes anti-inflammatory proteins including the "T" regulatory cells ( Protector proteins ).
- Cannabis Promotes regeneration, eg. neurogenesis (brain/nerve regrowth), cellular, & Bone regrowth.
Rheumatoid arthritist.
Most Severe: Rheumatiod & Cannabis
Most Severe: Rheumatiod & Cannabis
Rheumatoid arthritis (RA) is a disorder in which the body's own immune system starts to attack body tissues. The attack is not only directed at the joint but to many other parts of the body. In rheumatoid arthritis, most damage occurs to the joint lining and cartilage which eventually results in erosion of two opposing bones. RA often affects joints in the fingers, wrists, knees and elbows, is symmetrical (appears on both sides of the body), and can lead to severe deformity in a few years if not treated. RA occurs mostly in people aged 20 and above. In children, the disorder can present with a skin rash, fever, pain, disability, and limitations in daily activities. With earlier diagnosis and aggressive treatment, many individuals can lead a better quality of life than if going undiagnosed for long after RA's onset. The drugs to treat RA range from corticosteroids to monoclonal antibodies given intravenously.
Treatments: also include analgesics such as NSAIDs and disease-modifying antirheumatic drugs (DMARDs), while in rare cases, surgery may be required to replace joints, but there is no cure for the disease.
Treatment with DMARDs is designed to initiate an adaptive immune response, in part by CD4+ T helper (Th) cells, specifically Th17 cells. Th17 cells are present in higher quantities at the site of bone destruction in joints and produce inflammatory cytokines associated with inflammation, such as interleukin-17 (IL-17).
Bone erosion is a central feature of rheumatoid arthritis. Bone continuously undergoes remodeling by actions of bone resorbing osteoclasts and bone forming osteoblasts. One of the main triggers of bone erosion in the joints in rheumatoid arthritis is inflammation of the synovium, caused in part by the production of pro-inflammatory cytokines and receptor activator of nuclear factor kappa B ligand (RANKL), a cell surface protein present in Th17 cells and osteoblasts. Osteoclast activity can be directly induced by osteoblasts through the RANK/RANKL mechanism.
Direct benefits of Cannabis & Rheumatoid
Bone Cartilage & Connective tissue
Retrograde CB1 signaling will inhibit the release of the norepinephrine and alleviate this tonic sympathetic restraint, thus allowing bone to form as well Cells in other connective tissues through both CB 1 & 2 receptors. Cannabinoids have also shown to prevent cartilage destruction by inhibiting chondrocyte expression of cytokines and metalloproteinase enzymes.
Central Nervous System Pain & Cannabis
Cannabinoid Agonists
Cannabinoid receptors type 1 (CB1) are located at multiple locations in the peripheral and central nervous system, whereas CB2 receptors are located on inflammatory cells (monocytes, B/T cells, mast cells). CB2 activation results in a reduction in inflammatory mediator release, plasma extravasation, and sensory terminal sensitization. Activation of peripheral CB1 receptors results in a reduction in the release of pro-inflammatory terminal peptides and a reduction in terminal sensitivity. Activation of central CB1 receptors leads to reduced dorsal horn excitability and activates descending inhibitory pathways in the brain. The net result is a reduction in both pain and hyperalgesia. Inhaled cannabis has been extensively studied in various pain syndromes with mixed results. More recent well-controlled trials in neuropathic pain have shown promise.118 Sativex is a sublingual spray containing a mixture of tetrahydrocannabinol and cannabidiol, has been shown to reduce the pain of rheumatoid arthritis and chronic pain of various other causes.119
- Cannabis supresses the protein Cytokines,
- Promotes anti-inflammatory proteins including the "T" regulatory cells ( Protector proteins ).
- Cannabis Promotes regeneration, eg. neurogenesis (brain/nerve regrowth), cellular, & Bone regrowth
- The Functions of the Endocannabiniod System in regulation of All other functioning system, Specifically the Immune System, working hand in hand creating homeostasis.
- Modulating gene expression to homeostasis.
Treatments: also include analgesics such as NSAIDs and disease-modifying antirheumatic drugs (DMARDs), while in rare cases, surgery may be required to replace joints, but there is no cure for the disease.
Treatment with DMARDs is designed to initiate an adaptive immune response, in part by CD4+ T helper (Th) cells, specifically Th17 cells. Th17 cells are present in higher quantities at the site of bone destruction in joints and produce inflammatory cytokines associated with inflammation, such as interleukin-17 (IL-17).
Bone erosion is a central feature of rheumatoid arthritis. Bone continuously undergoes remodeling by actions of bone resorbing osteoclasts and bone forming osteoblasts. One of the main triggers of bone erosion in the joints in rheumatoid arthritis is inflammation of the synovium, caused in part by the production of pro-inflammatory cytokines and receptor activator of nuclear factor kappa B ligand (RANKL), a cell surface protein present in Th17 cells and osteoblasts. Osteoclast activity can be directly induced by osteoblasts through the RANK/RANKL mechanism.
Direct benefits of Cannabis & Rheumatoid
Bone Cartilage & Connective tissue
Retrograde CB1 signaling will inhibit the release of the norepinephrine and alleviate this tonic sympathetic restraint, thus allowing bone to form as well Cells in other connective tissues through both CB 1 & 2 receptors. Cannabinoids have also shown to prevent cartilage destruction by inhibiting chondrocyte expression of cytokines and metalloproteinase enzymes.
Central Nervous System Pain & Cannabis
Cannabinoid Agonists
Cannabinoid receptors type 1 (CB1) are located at multiple locations in the peripheral and central nervous system, whereas CB2 receptors are located on inflammatory cells (monocytes, B/T cells, mast cells). CB2 activation results in a reduction in inflammatory mediator release, plasma extravasation, and sensory terminal sensitization. Activation of peripheral CB1 receptors results in a reduction in the release of pro-inflammatory terminal peptides and a reduction in terminal sensitivity. Activation of central CB1 receptors leads to reduced dorsal horn excitability and activates descending inhibitory pathways in the brain. The net result is a reduction in both pain and hyperalgesia. Inhaled cannabis has been extensively studied in various pain syndromes with mixed results. More recent well-controlled trials in neuropathic pain have shown promise.118 Sativex is a sublingual spray containing a mixture of tetrahydrocannabinol and cannabidiol, has been shown to reduce the pain of rheumatoid arthritis and chronic pain of various other causes.119
- Cannabis supresses the protein Cytokines,
- Promotes anti-inflammatory proteins including the "T" regulatory cells ( Protector proteins ).
- Cannabis Promotes regeneration, eg. neurogenesis (brain/nerve regrowth), cellular, & Bone regrowth
- The Functions of the Endocannabiniod System in regulation of All other functioning system, Specifically the Immune System, working hand in hand creating homeostasis.
- Modulating gene expression to homeostasis.
Lupus
Main article: Lupus erythematosus
Lupus is a common collagen vascular disorder that can be present with severe arthritis. Other features of lupus include a skin rash, extreme photosensitivity, hair loss, kidney problems, lung fibrosis and constant joint pain.
Gout
Gouty Arthritis: Gout
Gout is caused by deposition of uric acid crystals in the joint, causing inflammation. There is also an uncommon form of gouty arthritis caused by the formation of rhomboid crystals of calcium pyrophosphate known as pseudogout. In the early stages, the gouty arthritis usually occurs in one joint, but with time, it can occur in many joints and be quite crippling. The joints in gout can often become swollen and lose function. Gouty arthritis can become particularly painful and potentially debilitating when gout cannot successfully be treated. When uric acid levels and gout symptoms cannot be controlled with standard gout medicines that decrease the production of uric acid (e.g., allopurinol, febuxostat) or increase uric acid elimination from the body through the kidneys (e.g., probenecid), this can be referred to as refractory chronic gout or RCG.
Main article: Lupus erythematosus
Lupus is a common collagen vascular disorder that can be present with severe arthritis. Other features of lupus include a skin rash, extreme photosensitivity, hair loss, kidney problems, lung fibrosis and constant joint pain.
Gout
Gouty Arthritis: Gout
Gout is caused by deposition of uric acid crystals in the joint, causing inflammation. There is also an uncommon form of gouty arthritis caused by the formation of rhomboid crystals of calcium pyrophosphate known as pseudogout. In the early stages, the gouty arthritis usually occurs in one joint, but with time, it can occur in many joints and be quite crippling. The joints in gout can often become swollen and lose function. Gouty arthritis can become particularly painful and potentially debilitating when gout cannot successfully be treated. When uric acid levels and gout symptoms cannot be controlled with standard gout medicines that decrease the production of uric acid (e.g., allopurinol, febuxostat) or increase uric acid elimination from the body through the kidneys (e.g., probenecid), this can be referred to as refractory chronic gout or RCG.
Clinical Studies
Study - 2006, Sept. - The Endocannabinoid System as an Emerging Target of Pharmacotherapy.
Study - 2009. - Cannabiniod-induced apoptosis in immune cells as a pathway to immune suppression.
Study - 2014. - Marijuana shows potential in treating autoimmune disease
Study - 2009. - Cannabiniod-induced apoptosis in immune cells as a pathway to immune suppression.
Study - 2014. - Marijuana shows potential in treating autoimmune disease
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found that "it is reasonable to consider cannabinoids as a treatment option for the management of chronic neuropathic pain, with evidence of efficacy in other types of chronic pain, such as fibromyalgia and rheumatoid arthritis as well."
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said that cannabis may be an effective treatment for joint pain. And a study published in the American Pain Society's Journal of Pain showed that patients who used marijuana for one year to treat general chronic pain had reduced discomfort and no serious side effects.
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Patents
29 Zurier et al., "Dimethylheptyl-THC-11 OIC Acid," Arthritis & Rheumatism, 41(1):163-170 (1998).
* Cited by examiner
US6410588B1 1998-04-14 2002-06-25 Anti-inflammatory Agent: The Mathilda And Terence Kennedy Institute Of Rheumatology Use of cannabinoids as anti-inflammatory agents
US6630507 Autoimmune Disorders; Cannabiniods as antioxidants & neuroprotectants (eg Rheumatism Arthritis)
For More Clinical Studies Check Out,
* Cited by examiner
US6410588B1 1998-04-14 2002-06-25 Anti-inflammatory Agent: The Mathilda And Terence Kennedy Institute Of Rheumatology Use of cannabinoids as anti-inflammatory agents
US6630507 Autoimmune Disorders; Cannabiniods as antioxidants & neuroprotectants (eg Rheumatism Arthritis)
For More Clinical Studies Check Out,
- List of Cannabis Studies
- List of Endocannabiniods & Cannabis Studies
- List of THC & Cannabis Studies
- List of CBD & Cannabis Studies