~ Depression ~

Page Legend
  • Preferred Strains
  • Methods to Medicate
  • Videos
  • ​Overview
  • How Cannabis Aids
  • Clinical Studies
Preferred Strains
Blue Dream
Northern Lights
OG Kush
Critical Kush
THC 14.36/19.38%
​CBD  ​1.05/1.77%
​CBN 0.51/2.66%
THC/CBD Ratio
​60/40% Sativa Dominant
THC 17.0/20.0%
​CBD 0.10/13.21%
CBN 0.30/0.70%
90/10% Indica Dominant
THC 16.00/20.00%
​CBD 0.10/0.30%
​CBN 0.0/0.30%
THC/CBD RATIO
​55/45% Sativa Dominant
THC 21.5/25.0%
​CBD 0.01/0.32%
CBN 0.01/0.05%
​THC/CBD Ratio
​90/10% Indica Dominant
Jack Herer
4.4
THC 18.0/23.0%
​CBD 0.03/0.2%
CBN 0.0/0.03%
THC/CBD Ratio
​Sativa Dominant
Harlequin
4.3
THC 4.0/7.0%
CBD 8.0/16.0%
CBN0.0/0.02%
​THC/CBD Ratio 2:5
​75/25% Sativa Dominant
THC 16.00/25.00%
​CBD 0.10/1.10%
​CBN 0.05/0.52%
​60/40% Sativa Dominant
Preferred Methods to Medicate
  • Vapor
  • Inhalers/Nebulizers
  • Smoking
  • Edibles/Capsules
  • Ointments/Topical
  • Tincture
  • Cannabis Oil
  • Sprays
  • Transdermal Patches
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Depression
13 Clinical Studies
​CBD oil for depression:
although CBD is very good for many ailments, but THC is a part of the matrix, also aiding, as the CB1  receptor is largely in the brain and nervous system, and depression is a mental/mood disorder ( the brain) 
Kxan ABC News
Cannabis Treating postpartum depression
Moms secretly treating postpartum depression with cannabis
​Changing the mother and the childs life for the better, without the side affects. ( Ignore the scare tactic at the end, & check out clinical studies below ).
Depression, Overview:
Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, feelings, and sense of well-being. A depressed mood is a normal temporary reaction to life events such as loss of a loved one. It is also a symptom of some physical diseases and a side effect of some drugs and medical treatments. Depressed mood is also a symptom of some mood disorders such as major depressive disorder or dysthymia.
"Despair" redirects here. For other uses of despair, see Despair (disambiguation). For the mood disorder, see Major depressive disorder.  "Hopelessness" redirects here. For the album by ANOHNI, see Hopelessness (album).
People with a depressed mood may be notably sad, anxious, or empty; they may also feel notably hopeless, helpless, dejected, or worthless. Other symptoms expressed may include senses of guilt, irritability, or anger. Further feelings expressed by these individuals may include feeling ashamed or an expressed restlessness. These individuals may notably lose interest in activities that they once considered pleasurable to family and friends or otherwise experience either a loss of appetite or overeating. Experiencing problems concentrating, remembering general facts or details, otherwise making decisions or experiencing relationship difficulties may also be notable factors in these individuals' depression and may also lead to their attempting or actually dying by suicide.
Expressed insomnia, excessive sleeping, fatigue, and vocalizing general aches, pains, and digestive problems and a reduced energy may also be present in individuals experiencing depression.
Depression
Cannabis Treating Depression
​Dr. Rachna Patel Discussing cannabis and clinical studies.
How Cannabis Aids:
​Endocannabiniods, CB 1 Receptors, 80/90% located in the Brain & Nervous System.
Serotonin is a Neurotransmitter, that regulates the mood.
known for many years, that depletion of the neurotransmitter serotonin in the brain leads to depression.  
The anti-depressant and intoxicating effects of cannabis are due to its chemical similarity to natural substances in the brain known as "endo-cannabinoids," which are released under conditions of high stress or pain, They interact with the brain through structures called cannabinoid CB1 receptors.  these receptors have a direct effect on the cells producing serotonin, (cannabinoids increase activity in the neurons that produce serotonin) which is a neurotransmitter that regulates the mood.  
​Neurogenesis: Re-growing brain cells
In the mammalian brain, the CB1 receptor is one of the most abundant G protein–coupled receptors, accounting for most, if not all, of the centrally mediated effects of cannabinoids (5). both embryonic and adult hippocampal NS/PCs express CB1 receptors. The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs)
Figure 1
Expression of CB1 receptors in NS/PCs. (A) Coimmunofluorescent staining of CB1 and nestin in cultured hippocampal NS/PCs derived from E17 embryos. Hoechst staining was conducted to reveal the total cultured cells. The arrow indicates the glial-like cells, ...
capable of generating new neurons, i.e., neurogenesis. Most drugs of abuse examined to date decrease adult hippocampal neurogenesis, but the effects of cannabis (marijuana or cannabinoids) on hippocampal neurogenesis DOES promote neurogenesis. This study aimed at investigating the potential regulatory capacity of the potent synthetic cannabinoid HU210 on hippocampal neurogenesis and its possible correlation with behavioral changeis below in clinical studies. The hippocampal NS/PCs are immunoreactive for CB1 cannabinoid receptors, indicating that cannabinoids act on CB1 receptors to regulate neurogenesis. This hypothesis is supported by further findings that HU210 promotes proliferation, but not differentiation, of cultured embryonic hippocampal NS/PCs likely via a sequential activation of CB1 receptors, Gi/o proteins, and ERK signaling. Chronic, but not acute, HU210 treatment promoted neurogenesis in the hippocampal dentate gyrus of adult rats and exerted anxiolytic- and antidepressant-like effects. X-irradiation of the hippocampus blocked both the neurogenic and behavioral effects of chronic HU210 treatment, suggesting that chronic HU210 treatment produces anxiolytic- and antidepressant-like effects likely via promotion of hippocampal neurogenesis.
CBD is postulated to act as an agonist to the 5HT1areceptor. Activation of the 5HT1a receptor is understood to modulate the release of serotonin in the brain. This hypothesis was confirmed in a study in which mice were pretreated with a 5HT1a antagonist, the antidepressant effects of CBD were absent. Further evidence of the role of 5HT1a is given by the observed similarities of CBD and isapirone (a 5HT1a partial agonist) in public speaking model.
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Clinical Studies:

Study - 2005 ~ Nov 1; 115(11): 3104–3116. Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce                                                                            anxiolytic- and antidepressant-like effects
2005 - Study ~ New Antidepressant Drug Increases 'Brain's Own Cannabis'
2006 - Study ~ Decreased depression in marijuana users
2009 - Study ~ Impairments in Endocannabinoid Signaling and Depressive Illness.
​Study - 2013 ~ Apr;226(4):781-92  Cannabidiol enhances consolidation of explicit fear extinction in humans.

Patents
US6630507  Cannabiniods as antioxidants & neuroprotectants​
For More Clinical Studies Check out, For More Cannabis Patents Check out,