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Changing Medicine Together!
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~ Autoimmune Disease ~
Systemic Lupus, Type 1 Diabetes, Celiac, Psoriasis, Rheumatoid Arthritis, Multiple Sclerosis, etc.
Patents
US6630507 Autoimmune Disorders; Cannabiniods as antioxidants & neuroprotectants
US6410588B1 1998-04-14 2002-06-25 anti-inflammatory agents The Mathilda And Terence Kennedy Institute Of Rheumatology Use of cannabinoids as anti-inflammatory agents
US6410588B1 1998-04-14 2002-06-25 anti-inflammatory agents The Mathilda And Terence Kennedy Institute Of Rheumatology Use of cannabinoids as anti-inflammatory agents
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Note: Autoimmune Disorder, is responsible for over 100 diseases, from rheumatoid arthritis, lupus, type 1 diabetes, celiac, psoriasis, multiple sclerosis & on. There is clearly a link (hence the summarized title, Autoimmune) although the clear differences, eg. Arthritis, Lupus. This aspect makes it difficult for big Pharma to Band-Aid the problem. Studies show people with Autoimmune, have a increase of Cannabiniod receptors in curtain areas, suggesting the body is in need of more Cannabiniods. Research has discovered that endocannabinoids are immunomodulators.
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Although Cannabis does NOT cure all of the Autoimmune disorders, it is very beneficial in all cases, as the Endocannabiniod System regulates all major organs and functioning bodily systems, eg. Immune, Nervous, Digestive, Lymph, etc. It Promotes Homeostasis throughout the body.
Cannabis has Regenerative functionalities ( in cells, neurons, muscle, vitamins, minerals, bone, etc), Assists in vitamin transport, enhancement, & synthesis, cannabis Activates the appropriate proteins & enzymes the body requires, all the while supressing the harmful proteins & enzymes, it Produces H2O2 which produces oxygen, and even decalcifies/plaque dissolving. With all these properties &
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much more, with no adverse side affects Cannabis is clearly the safe and beneficial treatment.
Preferred Strains:
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Preferred Methods to Medicate
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Ambary Education
CBD & Autoimmune Disease Basic Overview |
Cannabis & Health
Physician cover a detail description of health, cannabis & Cannabiniods |
Denmark Clinic
Physician Treating Autoimmune disorders with Cannabis |
Autoimmune Disorder, Overview:
Some of the most common autoimmune diseases include:
- Rheumatoid Arthritis (immune system attacks the cartilage in joints)
- Systemic Lupus (Irregular immune system affects a wide variety of organs, including kidneys, skin, joints, and brain)
- Celiac Disease (immune system begins to kill off tissue in the small intestine in response to gluten)
- Psoriasis (immune dysfunction in the skin)
- Hashimoto’s disease (immune system attacks the thyroid gland)
- Type 1 Diabetes (immune system attacks insulin-producing glands in the pancreas)
- Multiple Sclerosis (immune system attacks the myelin which surrounds neurons)
General Overview:
An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.[1] There are at least 80 types of autoimmune diseases.[1] Nearly any body part can be involved.[3] Common symptoms include low grade fever and feeling tired.[1] Often symptoms come and go.[1]
The cause is generally unknown,[3] although what we do know is, autoimmune disease can arises when a hyperactive immune system mistakes your own cells for a foreign invader, which can happen for a range of reasons. If your immune system is healthy, it seeks out and defends your body against pathogens.
Each time they encounter one of these pathogens, the immune system creates a special protein called an antibody in response.
These antibodies help the body take down very specific threats. In autoimmune disease, your body develops and produces these antibodies in response to very specific organ tissues.
These antibodies act as signals to let the immune system know that these are tissues to be targeted. Once something is flagged with an antibody, special cells called T-Cells do the dirty work and destroy whatever has been marked.
These antibodies can be made in response to all sorts of things. In some autoimmune diseases, antibodies against neurons in the brain are abundant. In others, you may find antibodies against specific types of cell receptors or enzymes.
Some autoimmune diseases such as lupus run in families, and certain cases may be triggered by infections or other environmental factors.[1] Some common diseases that are generally considered autoimmune include celiac disease, diabetes mellitus type 1, Graves' disease, inflammatory bowel disease, multiple sclerosis, psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.[1][4] The diagnosis can be difficult to determine.[1] About 24 million (7%) people in the United States are affected by an autoimmune disease.[1][3] Women are more commonly affected than men.[1] Often they start during adulthood.[1] The first autoimmune diseases were described in the early 1900s.[5]
An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.[1] There are at least 80 types of autoimmune diseases.[1] Nearly any body part can be involved.[3] Common symptoms include low grade fever and feeling tired.[1] Often symptoms come and go.[1]
The cause is generally unknown,[3] although what we do know is, autoimmune disease can arises when a hyperactive immune system mistakes your own cells for a foreign invader, which can happen for a range of reasons. If your immune system is healthy, it seeks out and defends your body against pathogens.
Each time they encounter one of these pathogens, the immune system creates a special protein called an antibody in response.
These antibodies help the body take down very specific threats. In autoimmune disease, your body develops and produces these antibodies in response to very specific organ tissues.
These antibodies act as signals to let the immune system know that these are tissues to be targeted. Once something is flagged with an antibody, special cells called T-Cells do the dirty work and destroy whatever has been marked.
These antibodies can be made in response to all sorts of things. In some autoimmune diseases, antibodies against neurons in the brain are abundant. In others, you may find antibodies against specific types of cell receptors or enzymes.
Some autoimmune diseases such as lupus run in families, and certain cases may be triggered by infections or other environmental factors.[1] Some common diseases that are generally considered autoimmune include celiac disease, diabetes mellitus type 1, Graves' disease, inflammatory bowel disease, multiple sclerosis, psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.[1][4] The diagnosis can be difficult to determine.[1] About 24 million (7%) people in the United States are affected by an autoimmune disease.[1][3] Women are more commonly affected than men.[1] Often they start during adulthood.[1] The first autoimmune diseases were described in the early 1900s.[5]
Typical Treatments
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Treatment depends on the type and severity of the condition.[1] Nonsteroidal anti-inflammatory drugs (NSAIDs) and immunosuppressants are often used.[1] Intravenous Immunoglobulin may also occasionally be used.[2] While treatment usually improves symptoms they do not typically cure the disease.[1]
~ How Cannabis Aids ~
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General Overview:
In autoimmune disease, your immune system continues to target and attack the same areas repeatedly. instantly causing inflammation. It’s like you have an infection that will never heal. In order to regain and maintain function in whatever tissue is being attacked, you need to calm the immune response and cut down inflammation. When inflammation happens in an organ or another part of your body, it simply cannot work very well, and Losing the functionality of any body part is disastrous to long-term health, can contribute to a cascade of other symptoms, and can even cost you your life.
In autoimmune disease, your immune system continues to target and attack the same areas repeatedly. instantly causing inflammation. It’s like you have an infection that will never heal. In order to regain and maintain function in whatever tissue is being attacked, you need to calm the immune response and cut down inflammation. When inflammation happens in an organ or another part of your body, it simply cannot work very well, and Losing the functionality of any body part is disastrous to long-term health, can contribute to a cascade of other symptoms, and can even cost you your life.
- Cannabis Synthesis neurogenesis
- Modulation of neurotransmitter release
- cannabis modulates gene transcriptionin this case, changes to specific molecules of epigenome called Histones. Histones help control gene expression. The research found that THC can modulate changes to Histones in a way that also suppresses inflammation.
- Cannabis Activates "T" Regulatory Cells. ( "T" Regulatory Cells actively prevent body from attacking itself. Regulatory T cells (Tregs) are critical to the maintenance of immune cell homeostasis as evidenced by the catastrophic consequences of genetic or physical ablation of the Treg population. Specifically, Treg cells maintain order in the immune system
- Cannabinoids downregulate/supress certain inflammatory proteins called cytokines.
- They found that CBD treatment caused levels of anti-inflammatory proteins increased.
- The endocannabinoid system regulates the immune system.
- Cannabiniods Aids in communications between body & the immune system as well act as messengers carrying the information
- Cannabis Promotes cell death in rogue cells.
Rheumatoid arthritis (RA) is a disorder in which the body's own immune system starts to attack body tissues. The attack is not only directed at the joint but to many other parts of the body. In rheumatoid arthritis, most damage occurs to the joint lining and cartilage which eventually results in erosion of two opposing bones. RA often affects joints in the fingers, wrists, knees and elbows, is symmetrical (appears on both sides of the body), and can lead to severe deformity in a few years if not treated.
Some Benefits of Cannabis:
- Cannabis Is a immunmodulator
- Cannabis supresses the protein Cytokines,
- Promotes anti-inflammatory proteins including the "T" regulatory cells ( Protector proteins ).
- Cannabis Promotes regeneration, eg. neurogenesis (brain/nerve regrowth), cellular, & Bone regrowth
Some Benefits of Cannabis:
- Cannabis Is a immunmodulator
- Cannabis supresses the protein Cytokines,
- Promotes anti-inflammatory proteins including the "T" regulatory cells ( Protector proteins ).
- Cannabis Promotes regeneration, eg. neurogenesis (brain/nerve regrowth), cellular, & Bone regrowth
Systemic Lupus:
Celiac Disease:
Psoriasis:
Type 1 Diabetes
Diabetes mellitus type 1Type 1 diabetes mellitus is characterized by loss of the insulin-producing beta cells of the pancreatic islets, leading to insulin deficiency. This type can be further classified as immune-mediated or idiopathic. The majority of type 1 diabetes is of the immune-mediated nature, in which a T cell-mediated autoimmune attack leads to the loss of beta cells and thus insulin.[
How Cannabis Aids:
Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases ( such as Rheumatoid Arthritis ). The cannabinoids are found to have particular application as neuroprotectants, & direct regulation to "T" regulatory Cells. For more on Diabetes
How Cannabis Aids:
Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases ( such as Rheumatoid Arthritis ). The cannabinoids are found to have particular application as neuroprotectants, & direct regulation to "T" regulatory Cells. For more on Diabetes
Multiple Sclerosis
Crohn's/Gastric Disease
Clinical Studies
2000 - Study ~ Endocannabinoids and fatty acid amides in cancer, inflammation and related disorders.
2004 - Study ~ New perspectives in the studies on endocannabinoid and cannabis: 2- arachidonoylglycerol as a possible novel mediator of inflammation
2004 - Study ~ Cannabinoids and neuroinflammation
2007 - Study ~ A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain.
2007 - Interview ~ Endocannabinoids, cannabinoid receptors and inflammatory stress: an interview with Dr. Pál Pacher
2007 - News ~ Constituents Of Hashish And Marijuana May Help To Fight Inflammation And Allergies
2007 - News ~ Pot Chemical May Curb Inflammation
2007 - News ~ Endocannabinoids appear to play important role in regulating inflammation
2007 - News ~ Hippies vindicated: Human-produced cannabinoids have anti-inflammatory powers
2006 - Study ~ Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and 2007 - Study ~ The endocannabinoid system in targeting inflammatory neurodegenerative diseases
2007 - Study ~ Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic painic Pain Episodes
2009 - Study ~ Cannabinoids Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells.
2009 - Study ~ Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4.
2009 - Study ~ Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease.
2009 - Study ~ Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death.
2009 - Study - Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats.
2009 - Study ~ Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects.
2010 - Study ~ Regulatory Role of Cannabinoid Receptor 1 in Stress-Induced Excitotoxicity and Neuroinflammation.
2010 - Study ~ Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression.
Study - 2007 ~ Cannabinoids and neuroprotection in motor-related disorders.
6, Sept. - The Endocannabinoid System as an Emerging Target of Pharmacotherapy.
Study - 2009. - Cannabiniod-induced apoptosis in immune cells as a pathway to immune suppression.
2011 - Study ~ Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ(9) -tetrahydrocannabinol in BV-2 microglial cells.
2012 - Study ~ Endocannabinoids alleviate proinflammatory conditions by modulating innate immune response in muller glia during inflammation.
2012 - Study ~ Cannabinoid receptor-2-selective agonists improve recovery in experimental autoimmune encephalomyelitis.
2012 - Study ~ Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?
2012 - Study ~ The endocannabinoid system: a revolving plate in neuro-immune interaction in health and disease.
Study - 2014. - Marijuana shows potential in treating autoimmune disease
2004 - Study ~ New perspectives in the studies on endocannabinoid and cannabis: 2- arachidonoylglycerol as a possible novel mediator of inflammation
2004 - Study ~ Cannabinoids and neuroinflammation
2007 - Study ~ A cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain.
2007 - Interview ~ Endocannabinoids, cannabinoid receptors and inflammatory stress: an interview with Dr. Pál Pacher
2007 - News ~ Constituents Of Hashish And Marijuana May Help To Fight Inflammation And Allergies
2007 - News ~ Pot Chemical May Curb Inflammation
2007 - News ~ Endocannabinoids appear to play important role in regulating inflammation
2007 - News ~ Hippies vindicated: Human-produced cannabinoids have anti-inflammatory powers
2006 - Study ~ Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and 2007 - Study ~ The endocannabinoid system in targeting inflammatory neurodegenerative diseases
2007 - Study ~ Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic painic Pain Episodes
2009 - Study ~ Cannabinoids Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells.
2009 - Study ~ Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4.
2009 - Study ~ Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease.
2009 - Study ~ Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death.
2009 - Study - Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats.
2009 - Study ~ Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects.
2010 - Study ~ Regulatory Role of Cannabinoid Receptor 1 in Stress-Induced Excitotoxicity and Neuroinflammation.
2010 - Study ~ Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression.
Study - 2007 ~ Cannabinoids and neuroprotection in motor-related disorders.
6, Sept. - The Endocannabinoid System as an Emerging Target of Pharmacotherapy.
Study - 2009. - Cannabiniod-induced apoptosis in immune cells as a pathway to immune suppression.
2011 - Study ~ Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ(9) -tetrahydrocannabinol in BV-2 microglial cells.
2012 - Study ~ Endocannabinoids alleviate proinflammatory conditions by modulating innate immune response in muller glia during inflammation.
2012 - Study ~ Cannabinoid receptor-2-selective agonists improve recovery in experimental autoimmune encephalomyelitis.
2012 - Study ~ Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?
2012 - Study ~ The endocannabinoid system: a revolving plate in neuro-immune interaction in health and disease.
Study - 2014. - Marijuana shows potential in treating autoimmune disease
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found that "it is reasonable to consider cannabinoids as a treatment option for the management of chronic neuropathic pain, with evidence of efficacy in other types of chronic pain, such as fibromyalgia and rheumatoid arthritis as well."
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Patents
29 Zurier et al., "Dimethylheptyl-THC-11 OIC Acid," Arthritis & Rheumatism, 41(1):163-170 (1998).
* Cited by examiner
US6630507 Autoimmune Disorders; Cannabiniods as antioxidants & neuroprotectants
US6410588B1 1998-04-14 2002-06-25 anti-inflammatory agents The Mathilda And Terence Kennedy Institute Of Rheumatology Use of cannabinoids as anti-inflammatory agents
For More Clinical Studies Check Out,
29 Zurier et al., "Dimethylheptyl-THC-11 OIC Acid," Arthritis & Rheumatism, 41(1):163-170 (1998).
* Cited by examiner
US6630507 Autoimmune Disorders; Cannabiniods as antioxidants & neuroprotectants
US6410588B1 1998-04-14 2002-06-25 anti-inflammatory agents The Mathilda And Terence Kennedy Institute Of Rheumatology Use of cannabinoids as anti-inflammatory agents
For More Clinical Studies Check Out,
- List of Cannabis Studies
- List of Endocannabiniods & Cannabis Studies
- List of THC & Cannabis Studies
- List of CBD & Cannabis Studies
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