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Changing Medicine Together!
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~ Inflammation ~
Patent
US6410588B1 1998-04-14 2002-06-25 Anti-inflammatory Agent: The Mathilda And Terence Kennedy Institute Of Rheumatology Use of cannabinoids as anti-inflammatory agents
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Note: Inflammation is commonly from a injury but is often a autoimmune disorder as well.
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Note: Autoimmune Disorder, is responsible for over 100 diseases, from rheumatoid arthritis, lupus, type 1 diabetes, celiac, psoriasis, multiple sclerosis & on. There is clearly a link (hence the summarized title, Autoimmune) although the clear differences, eg. Arthritis, Lupus. This aspect makes it difficult for big Pharma to Band-Aid the problem. Studies show people with Autoimmune; Rheumatoid Arthritis (Which is a autoimmune inflammatiory issue), have a increase of Cannabiniod receptors in curtain areas, suggesting the body is in need of more Cannabiniods. Research has discovered that endocannabinoids are immunomodulators.
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Although Cannabis does NOT cure all of the Autoimmune disorders, it is very beneficial in all cases, as the Endocannabiniod System regulates all major organs and functioning bodily systems, eg. Immune, Nervous, Digestive, Lymph, etc. It Promotes Homeostasis throughout the body.
Cannabis has Regenerative functionalities ( in cells, neurons, muscle, vitamins, minerals, bone, etc), Assists in vitamin transport, enhancement, & synthesis, cannabis Activates the appropriate proteins & enzymes the body requires, all the while supressing the harmful proteins & enzymes, it Produces H2O2 which produces |
oxygen, and even decalcifies/plaque dissolving. With all these properties & much more, with no adverse side affects Cannabis is clearly the safe and beneficial treatment.
Preferred strains
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THC 21.0/25.0%
CBD O.0/0.6% CBN 0.O/O.3% 75/25% Indica Dominant |
THC 0.42/1.20%
CBD 16.0/24.0% CBN 0.0/0.20% THC/CBD Ratio 1:20 |
THC 15.0/23.0%
CBD 0.01/0.07% CBN -/-% 80/20 Indica Dominant |
THC 4.0/7.0%
CBD 8.0/16.0% CBN0.0/0.02% THC/CBD Ratio 2:5 75/25% Sativa Dominant |
Preferred Method to Medicate
Note: Depending on the type of inflammation, will dictate the method to medicate. whether topically or internal.
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Dr. Blair
CBD (Cannabis) Treating Inflammation Inflammation is responsible for a range of chronic diseases. |
Brain Inflammation
Benefits of Cannabis Gary Wenk, professor of Psychology & Neuroscience, at the Ohio State University. |
Overview
Cannabis Treating Inflammation Inflammation can occur anywhere in the body |
Inflammation
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Inflammation (from Latin inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants,[1] and is a protective response involving immune cells, blood vessels, and molecular mediators. The function of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and the inflammatory process, and initiate tissue repair.
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The classical signs of inflammation are heat, pain, redness, swelling, and loss of function. Inflammation is a generic response, and therefore it is considered as a mechanism of innate immunity, as compared to adaptive immunity, which is specific for each pathogen.[2] Too little inflammation could lead to progressive tissue destruction by the harmful stimulus (e.g. bacteria) and compromise the survival of the organism. In contrast, chronic inflammation may lead to a host of diseases, such as hay fever, periodontitis, atherosclerosis, rheumatoid arthritis, and even cancer (e.g., gallbladder carcinoma). Inflammation is therefore normally closely regulated by the body.
Inflammation can be classified as either acute or chronic. Acute inflammation is the initial response of the body to harmful stimuli and is achieved by the increased movement of plasma and leukocytes (especially granulocytes) from the blood into the injured tissues. A series of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, and various cells within the injured tissue. Prolonged inflammation, known as chronic inflammation, leads to a progressive shift in the type of cells present at the site of inflammation, such as mononuclear cells, and is characterized by simultaneous destruction and healing of the tissue from the inflammatory process.
Inflammation can be classified as either acute or chronic. Acute inflammation is the initial response of the body to harmful stimuli and is achieved by the increased movement of plasma and leukocytes (especially granulocytes) from the blood into the injured tissues. A series of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, and various cells within the injured tissue. Prolonged inflammation, known as chronic inflammation, leads to a progressive shift in the type of cells present at the site of inflammation, such as mononuclear cells, and is characterized by simultaneous destruction and healing of the tissue from the inflammatory process.
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Inflammation is not a synonym for infection. Infection describes the interaction between the action of microbial invasion and the reaction of the body's inflammatory response — the two components are considered together when discussing an infection, and the word is used to imply a microbial invasive cause for the observed inflammatory reaction. Inflammation on the other hand describes purely the body's immunovascular response, whatever the cause may be. But because of how often the two are correlated, words ending in the suffix -itis (which refers to inflammation) are sometimes informally described as referring to infection. For example, the word urethritis strictly means only "urethral inflammation", but clinical health care providers usually discuss urethritis as a urethral infection because urethral microbial invasion is the most common cause of urethritis.
It is useful to differentiate inflammation and infection as there are many pathological situations where inflammation is not driven by microbial invasion – for example, atherosclerosis, type III hypersensitivity, trauma, ischaemia. There are also pathological situations where microbial invasion does not result in classic inflammatory response—for example, parasitosis, eosinophilia. How Cannabis Aids:
Cannabis has several functions known to date that aid in helping inflammation, including indirectly, by regulating/creating homeostasis through the bodily systems.
Directly aiding by: 1- Research from 2014 made the groundbreaking discovery that cannabis: modulates changes to specific molecules called histones. Histones help control gene expression. The research found that THC can cause changes to histones in a way that suppresses inflammation. 2 - Further, studies have shown that: cannabinoids downregulate/supress certain inflammatory proteins called cytokines. 3 - They found that CBD treatment caused levels of pro-inflammatory cytokines to decrease, all the while levels of anti-inflammatory proteins ie. the anti-inflammatory IL-10 are significantly elevated following CBD-treatment, combating existing inflammation. 4 - Cannabis activates T-regulatory cells, which prevent cells from attacking itself. eg.( Hyper active immune system). 5 - Cannabis promotes cell death in rogue cells. The immune imbalance was tentatively corrected by Cannabis as the endocannabinoid system regulates the immune system. Cannabis is such a powerful anti-inflammatory that it has been shown to aid in remission of Crohn’s Disease. Crohn’s is a bowel disease in which inflammation in the gut runs rampant. The endocannabinoid system and immune function
Cannabis compounds like psychoactive THC connect with special sites on cells called cannabinoid receptors. These receptors provide a way for your cells to receive messages and respond to the communication. In this case, messages come in the form of endocannabinoids. Endocannabinoids are the human version of THC. When you consume cannabis, active chemicals in the plant replace endocannabinoids at these receptor sites. Turns out, these receptors and chemicals help the immune system communicate with the rest of the body. Thus far, scientists have found two primary types of cannabinoid receptors, cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2). CB1 receptors are most abundant in the brain, but they are also found on immune cells. CB2 receptors are most abundant in immune cells. The presence of these receptor sites is a good indication that the ECS plays an important role in immune regulation. Research has discovered that endocannabinoids are immunomodulators. Endocannabinoid levels rise when there is a pathogen threat. They also have been described as negative modulators of the immune system. Simply stated, this means that the compounds help the immune system “balance" ( reach homeostasis). For more on the endocannabiniod system |
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An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.[1] There are at least 80 types of autoimmune diseases.[1] Nearly any body part can be involved.[3] autoimmune disease can arises when a hyperactive immune system mistakes your own cells for a foreign invader, amongst many problems arising from autoimmune disease like multiple sclerosis, oftena hyperactive immune system send inflammatory proteins to "X" locations to isolate the problem it thinks is there.
Some ways Cannabis Aids:
cannabis modulates changes to specific molecules called histones. Histones help control gene expression,
supress certain inflammatory proteins called cytokines. anti-inflammatory proteins increased. activates T-regulatory cells, promotes cell death in rogue cells, the endocannabinoid system regulates the immune system.
cannabis modulates changes to specific molecules called histones. Histones help control gene expression,
supress certain inflammatory proteins called cytokines. anti-inflammatory proteins increased. activates T-regulatory cells, promotes cell death in rogue cells, the endocannabinoid system regulates the immune system.
Arthritis is a term often used to mean any disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. In some types other organs are also affected. Onset can be gradual or sudden.
There are over 100 types of arthritis. The most common forms are osteoarthritis (degenerative joint disease) and rheumatoid arthritis. Osteoarthritis usually occurs with age and affects the fingers, knees, and hips. Rheumatoid arthritis is an autoimmune disease that often affects the hands and feet. Other types include gout, lupus, fibromyalgia, and septic arthritis. They are all types of rheumatic disease.
There are over 100 types of arthritis. The most common forms are osteoarthritis (degenerative joint disease) and rheumatoid arthritis. Osteoarthritis usually occurs with age and affects the fingers, knees, and hips. Rheumatoid arthritis is an autoimmune disease that often affects the hands and feet. Other types include gout, lupus, fibromyalgia, and septic arthritis. They are all types of rheumatic disease.
Lupus
Clinical Studies
Study - 2006, Sept. - The Endocannabinoid System as an Emerging Target of Pharmacotherapy.
Study - 2009. - Cannabiniod-induced apoptosis in immune cells as a pathway to immune suppression.
Study - 2014. - Marijuana shows potential in treating autoimmune disease
Study - 2009. - Cannabiniod-induced apoptosis in immune cells as a pathway to immune suppression.
Study - 2014. - Marijuana shows potential in treating autoimmune disease
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found that "it is reasonable to consider cannabinoids as a treatment option for the management of chronic neuropathic pain, with evidence of efficacy in other types of chronic pain, such as fibromyalgia and rheumatoid arthritis as well."
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US6410588B1 1998-04-14 2002-06-25 Anti-inflammatory Agent: The Mathilda And Terence Kennedy Institute Of Rheumatology Use of cannabinoids as anti-inflammatory agents