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Changing Medicine Together
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Note: Cannabinoid receptors are virtually absent in brainstem cardiorespiratory centers. This is why that there is no lethal overdose of cannabinoids/Cannabis.
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ABC News
Cannabis & Severe Autism With Such noticeable benefits, Mom was amazed & Started a awareness campaign. |
Fox News
Cannabis Treating Autism CBD rich cannabis |
ABC News
Autism & Cannabis Aiding in managing Autistic symptoms Making a difference |
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Autism, Overview:
Autism is a developmental disorder characterized by troubles with social interaction and communication, and by restricted and repetitive behavior.[3] Parents usually notice signs in the first two or three years of their child's life.[1][3] These signs often develop gradually, though some children with autism reach their developmental milestones at a normal pace and then worsen.[9]
Autism is caused by a combination of genetic and environmental factors.[4] Risk factors include certain infections during pregnancy such as rubella as well as valproic acid, alcohol, or cocaine use during pregnancy.[10] Controversies surround other proposed environmental causes; for example the vaccine hypotheses.[11] Autism affects information processing in the brain by altering how nerve cells and their synapses connect and organize; how this occurs is not well understood.[12] In the DSM V, autism is included within the autism spectrum (ASDs), along with Asperger syndrome which is less severe, and pervasive developmental disorder, not otherwise specified (PDD-NOS).[3][13] Early speech or behavioral interventions can help children with autism gain self-care, social, and communication skills.[6] Although there is no known cure,[6] there have been cases of children who recovered.[14] Not many children with autism live independently after reaching adulthood, though some are successful.[7] An autistic culture has developed, with some individuals seeking a cure and others believing autism should be accepted as a difference and not treated as a disorder.[15] With all that being said, it seems as if there was a chemical imbalance during development, seemingly from a overload of synthetic chemicals throwing off the production of properly functioning systems. With different severities it often appears as though the genetic coding the brain, nervous, immune ( Autoimmune) could all be a potential suspect Autism & Related Symptom/Syndromes
~ How Cannabis Aids ~
Overview: 
Autism spectrum disorder (ASD) defines a group of neurodevelopmental disorders whose symptoms include impaired communication and social interaction with restricted or repetitive motor movements, frequently associated with general cognitive deficits. Although it is among the most severe chronic childhood disorders in terms of prevalence, morbidity, and impact to the society, no effective treatment for ASD is yet available, possibly because its neurobiological basis is not clearly understood hence specific drugs have not yet been developed. Although it dose seem to have symptoms in the range of autoimmune disorders, which the cannabiniod system is directly involved in regulating, which can help aid, cannabis/ cannabiniods activate the (EC) system, reducing some to all symptoms on a occasion. The endocannabinoid (EC) system represents a major neuromodulatory system involved in the regulation of emotional responses, behavioral reactivity to context, and social interaction. Furthermore, the EC system is also affected in conditions often present in subsets of patients diagnosed with ASD, such as seizures, anxiety, intellectual disabilities, and sleep pattern disturbances. Despite the indirect evidence suggestive of an involvement of the EC system in ASD, only a few studies have specifically addressed the role of the EC system in the context of ASD. This review describes the available data on the investigation of the presence of alterations of the EC system as well as the effects of its pharmacological manipulations in animal models of ASD-like behaviors.
Cannabis is a well know supplement for the endocannabiniod system, mimicking the transmitter perfectly as well as bring a hole portfolio of medicinal/healing properties to add to the supplemental aid. balancing all biological system, homeostasis. There is a vasrt number of studies related to autistic symptoms, from nausea, to pain, to seizures and on. check out those catagories for more related detail to the pertaining symptom. Symptoms
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cannabinoids & Autism
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Autism relation to the ECS (Cannabiniods) & Immune System (Autoimmunity)
Immune System & ECS
Immune system dysregulation is well-recognized in autism and thought to be part of the etiology of this disorder. The endocannabinoid system is highly expressed throughout the entire Immune system, as it is a key regulator of the immune system , via the cannabinoid receptor type 2 (CB2R) ( CB 1 receptors are also found within the nervous system, but at a much smaller percentage), CB 2 which is also highly expressed, on macrophages and microglial cells with in the immune system. We have previously published significant differences in peripheral blood mononuclear cell CB2R gene expression in the autism population. The use of the Gc protein-derived Macrophage Activating Factor (GcMAF), an endogenous glycosylated vitamin D binding protein responsible for macrophage cell activation has demonstrated positive effects in the treatment of autistic children. In this current study, we investigated the in vitro effects of GcMAF treatment on the endocannabinoid system gene expression, as well as cellular activation in blood monocyte-derived macrophages (BMDMs) from autistic patients compared to age-matched healthy developing controls. This study presents the first observations of GcMAF effects on the transcriptionomics of the endocannabinoid system and expression of CB2R protein. These data point to a potential nexus between endocannabinoids, vitamin D and its transporter proteins, and the immune dysregulations observed with autism. We have found evidence that Cannabis/Cannabiniods regenerates minerals and nutrients, which would directly help with Autism as we are finding that vitmanin D has a important role in Autism as well as regulating the Immune System ( for any Autoimmune Issues ). Cannabis/Cannabiniods are also know for having Neuroprotectant & neurogenesis properties aiding right from the control room.
A 2013 study conducted by Dr. Dario Siniscalco found indications that certain compounds—namely the CB2 receptor—found in cannabis may be helpful in managing autism.
Immune system dysregulation is well-recognized in autism and thought to be part of the etiology of this disorder. The endocannabinoid system is highly expressed throughout the entire Immune system, as it is a key regulator of the immune system , via the cannabinoid receptor type 2 (CB2R) ( CB 1 receptors are also found within the nervous system, but at a much smaller percentage), CB 2 which is also highly expressed, on macrophages and microglial cells with in the immune system. We have previously published significant differences in peripheral blood mononuclear cell CB2R gene expression in the autism population. The use of the Gc protein-derived Macrophage Activating Factor (GcMAF), an endogenous glycosylated vitamin D binding protein responsible for macrophage cell activation has demonstrated positive effects in the treatment of autistic children. In this current study, we investigated the in vitro effects of GcMAF treatment on the endocannabinoid system gene expression, as well as cellular activation in blood monocyte-derived macrophages (BMDMs) from autistic patients compared to age-matched healthy developing controls. This study presents the first observations of GcMAF effects on the transcriptionomics of the endocannabinoid system and expression of CB2R protein. These data point to a potential nexus between endocannabinoids, vitamin D and its transporter proteins, and the immune dysregulations observed with autism. We have found evidence that Cannabis/Cannabiniods regenerates minerals and nutrients, which would directly help with Autism as we are finding that vitmanin D has a important role in Autism as well as regulating the Immune System ( for any Autoimmune Issues ). Cannabis/Cannabiniods are also know for having Neuroprotectant & neurogenesis properties aiding right from the control room.
A 2013 study conducted by Dr. Dario Siniscalco found indications that certain compounds—namely the CB2 receptor—found in cannabis may be helpful in managing autism.
Autisms Relation to The Nervous System & ECS
Nervous System & ECS
The CB1 receptor is the most common G-protein receptor found in the human brain. The highest densities of CB1 are found in the hippocampus, the cerebral cortex, the cerebellum, the amygdala nucleus, and the basal ganglia —areas of the brain involved with short-term memory, cognition, mood and emotion, motor function, and nociception. Cannabinoid receptors are virtually absent in brainstem cardiorespiratory centers. This is why that there is no lethal overdose of cannabinoids.
The function of the endocannabinoid system in the nervous system is more than just homeostatic prevention of too much excitation or too much inhibition. There is a significant protective and repair function, and the endocannabinoid system is heavily involved in neuroplasticity. Neuroplasticity involves the sprouting and pruning of synapses, changes in dendritic spine density, and changes in neurotransmitter pathways. It gives rise to all types of adaptive learning, including recovering from a stroke, the conscious act of gaining a new skill, and the unconscious acquisition of a new emotional response. It is also involved in pathological processes such as central sensitization to pain. There are multiple mechanisms by which cannabinoids modulate neural plasticity, including neurogenesis (the formation of new neurons), long-term potentiation and long-term depression. Research in humans has shown that the administration of exogenous cannabinoids can cause neuroplastic changes. One study that looked at volunteers who were heavy cannabis users found neuroplastic changes in the nucleus accumbens and amygdala. These are two areas of the brain that are involved in the enjoyment of activities
studies have shown that cannabinoids can enhance a process called fear extinction. Fear extinction is a neuroplastic event that’s essential for preventing and recovering from post-traumatic stress. Anandamide and 2-AG are also endogenous neuroprotective agents, produced by the nervous system in response to both chemical and mechanical trauma. Other phytocannabinoids and synthetic cannabinoids have been shown to decrease glutamate excitotoxicity in a situation of a seizure or a stroke. When neurons become injured or ill, they tend to release their contents. Excitatory neurons release levels of glutamate that become toxic to the surrounding cells, and we see a domino effect of excitotoxicity. Cannabinoids have been shown to halt that process. The United States Department of Health and Human Services actually owns a patent on the use of cannabinoids as anti-oxidants and neuroprotectants. The authors of this patent discuss the potential benefit of using cannabinoids in neurodegenerative conditions such as multiple sclerosis, Alzheimer’s, Parkinson’s, Huntington’s, and more. Cannabinoids also affect autonomic tone. In the sympathetic nervous system, CB1 receptor stimulation will inhibit noroepinephrine release. It will dampen sympathetically mediated pain and modulate the hypothalamic- pituitary-adrenal axis and the hypothalamic locus coerulius-norepinephrine axis.
The function of the endocannabinoid system in the nervous system is more than just homeostatic prevention of too much excitation or too much inhibition. There is a significant protective and repair function, and the endocannabinoid system is heavily involved in neuroplasticity. Neuroplasticity involves the sprouting and pruning of synapses, changes in dendritic spine density, and changes in neurotransmitter pathways. It gives rise to all types of adaptive learning, including recovering from a stroke, the conscious act of gaining a new skill, and the unconscious acquisition of a new emotional response. It is also involved in pathological processes such as central sensitization to pain. There are multiple mechanisms by which cannabinoids modulate neural plasticity, including neurogenesis (the formation of new neurons), long-term potentiation and long-term depression. Research in humans has shown that the administration of exogenous cannabinoids can cause neuroplastic changes. One study that looked at volunteers who were heavy cannabis users found neuroplastic changes in the nucleus accumbens and amygdala. These are two areas of the brain that are involved in the enjoyment of activities
studies have shown that cannabinoids can enhance a process called fear extinction. Fear extinction is a neuroplastic event that’s essential for preventing and recovering from post-traumatic stress. Anandamide and 2-AG are also endogenous neuroprotective agents, produced by the nervous system in response to both chemical and mechanical trauma. Other phytocannabinoids and synthetic cannabinoids have been shown to decrease glutamate excitotoxicity in a situation of a seizure or a stroke. When neurons become injured or ill, they tend to release their contents. Excitatory neurons release levels of glutamate that become toxic to the surrounding cells, and we see a domino effect of excitotoxicity. Cannabinoids have been shown to halt that process. The United States Department of Health and Human Services actually owns a patent on the use of cannabinoids as anti-oxidants and neuroprotectants. The authors of this patent discuss the potential benefit of using cannabinoids in neurodegenerative conditions such as multiple sclerosis, Alzheimer’s, Parkinson’s, Huntington’s, and more. Cannabinoids also affect autonomic tone. In the sympathetic nervous system, CB1 receptor stimulation will inhibit noroepinephrine release. It will dampen sympathetically mediated pain and modulate the hypothalamic- pituitary-adrenal axis and the hypothalamic locus coerulius-norepinephrine axis.
Cannabiniods/Cannabis
Heart & Sensitivity
Cannabioid receptors also have peripheral activities that affect autonomic tone: For example, myocardial CB1 receptors, when activated, cause vagally mediated biphasic effects in heart rate and cardiac contractility. Depending on the situation, stimulation of the CB1 receptors could increase or decrease heart rate and contractility. In vascular tissues CB1 activation causes vasodilation, which leads to an anti-hypertensive effect that has been demonstrated in humans.
Cannabioid receptors also have peripheral activities that affect autonomic tone: For example, myocardial CB1 receptors, when activated, cause vagally mediated biphasic effects in heart rate and cardiac contractility. Depending on the situation, stimulation of the CB1 receptors could increase or decrease heart rate and contractility. In vascular tissues CB1 activation causes vasodilation, which leads to an anti-hypertensive effect that has been demonstrated in humans.
Genes & Nervous System
Deficiency Syndroms/Potential Disregulations
migraine, M.S., Huntington’s, and Parkinson’s, I.B.S, anorexia, motion sickness, fibromyalgia, menstrual symptoms, etc!
Although cannabinoid deficiency syndromes have not yet been clearly defined in humans, there is some pre-clinical evidence and some human evidence that dysregulation of the endocannabinoid system is associated with several conditions. Endocannabinoid deficiencies have been implicated in schizophrenia, migraine, multiple sclerosis, Huntington’s, and Parkinson’s, irritable bowel syndrome, anorexia, motion sickness, fibromyalgia, menstrual symptoms, and other conditions that involve hyperalgesia and abnormal sensitization to pain. Several polymorphisms [differing forms] have been identified in the genes that code for the cannabinoid receptors. And Being the EC system is a regulatory system some of these polymorphisms have been associated with clinical outcomes, such as a tendency towards happiness or depression, and the likelihood of developing a post-traumatic stress disorder. Therefore if your coding ( gene transcription is off/incorrect, Phytocannabiniods can supplement (which are mimics to the cannabinoids proper form/coding & Cannabiniods/Phytocannabiniods have gene transcription modulation properties as well, potentially aiding in the correction of the improper coding or damper.
Deficiency Syndroms/Potential Disregulations
migraine, M.S., Huntington’s, and Parkinson’s, I.B.S, anorexia, motion sickness, fibromyalgia, menstrual symptoms, etc!
Although cannabinoid deficiency syndromes have not yet been clearly defined in humans, there is some pre-clinical evidence and some human evidence that dysregulation of the endocannabinoid system is associated with several conditions. Endocannabinoid deficiencies have been implicated in schizophrenia, migraine, multiple sclerosis, Huntington’s, and Parkinson’s, irritable bowel syndrome, anorexia, motion sickness, fibromyalgia, menstrual symptoms, and other conditions that involve hyperalgesia and abnormal sensitization to pain. Several polymorphisms [differing forms] have been identified in the genes that code for the cannabinoid receptors. And Being the EC system is a regulatory system some of these polymorphisms have been associated with clinical outcomes, such as a tendency towards happiness or depression, and the likelihood of developing a post-traumatic stress disorder. Therefore if your coding ( gene transcription is off/incorrect, Phytocannabiniods can supplement (which are mimics to the cannabinoids proper form/coding & Cannabiniods/Phytocannabiniods have gene transcription modulation properties as well, potentially aiding in the correction of the improper coding or damper.
Anti-inflammatory Properties
Autism has shown signs and symptoms of inflammation within the nervous system and brain, Cannabus/Cannabiniods are ideal for ant-inflammatory properties aiding in the Autistic symptoms.
Cannabis has several functions known to date that aid in helping inflammation, including indirectly, by regulating/creating homeostasis through the bodily systems.
Directly aiding by:
1- Research from 2014 made the groundbreaking discovery that cannabis:
modulates changes to specific molecules called histones. Histones help control gene expression. The research found that THC can cause changes to histones in a way that suppresses inflammation.
2 - Further, studies have shown that:
cannabinoids downregulate/supress certain inflammatory proteins called cytokines.
3 - They found that CBD treatment caused levels of pro-inflammatory cytokines to decrease, all the while levels of anti-inflammatory proteins ie. the anti-inflammatory IL-10 are significantly elevated following CBD-treatment, combating existing inflammation.
Autism has shown signs and symptoms of inflammation within the nervous system and brain, Cannabus/Cannabiniods are ideal for ant-inflammatory properties aiding in the Autistic symptoms.
Cannabis has several functions known to date that aid in helping inflammation, including indirectly, by regulating/creating homeostasis through the bodily systems.
Directly aiding by:
1- Research from 2014 made the groundbreaking discovery that cannabis:
modulates changes to specific molecules called histones. Histones help control gene expression. The research found that THC can cause changes to histones in a way that suppresses inflammation.
2 - Further, studies have shown that:
cannabinoids downregulate/supress certain inflammatory proteins called cytokines.
3 - They found that CBD treatment caused levels of pro-inflammatory cytokines to decrease, all the while levels of anti-inflammatory proteins ie. the anti-inflammatory IL-10 are significantly elevated following CBD-treatment, combating existing inflammation.
Message System/Regulatory/ECS
A study published in 2013 by Dr. Csaba Foldy at the Second University of Naples in association with Stanford University Medical School found that under developed/alterations in endocannabinoid signaling may contribute to autism. as mentioned above cannabiniods/cannabis can regulate a altered endocannabiniod system, while protecting neurons and generating neurons, aiding in regulating the EC system and aid it in it's functioning.
A study published in 2013 by Dr. Csaba Foldy at the Second University of Naples in association with Stanford University Medical School found that under developed/alterations in endocannabinoid signaling may contribute to autism. as mentioned above cannabiniods/cannabis can regulate a altered endocannabiniod system, while protecting neurons and generating neurons, aiding in regulating the EC system and aid it in it's functioning.
Autisms related Symptoms/Syndrome
Symptoms & Clinical Studies
Increasingly, parents of children with severe autism, frustrated with the lack of options, have turned to cannabis. Many have heard anecdotal reports of success; others have read of promising results with epileptic children. However, clinical research remains nonexistent. But forget about the elites lack of interest to solving the Autistic problem, if one looks at the clinical studies in related subjects, it's not hard to see the obvious benefits to Autism even if even only indirect. Educated assumption based off clinical studies, it does more.
Cannabiniods Aiding with Related Autistic Disorders
Mood/Social Disorders
According to the Autism Research Institute, some of the symptoms that MMJ have improved include “anxiety, aggression, panic disorder, generalized rage, tantrums, property destruction, and self-injurious behavior.” Through cannabis/cannabiniods regulatory properties both of there own & through the EC system creating homeostasis, the body receives a calming experience through the process of homeostasis aiding in calm. as well as releasing curtain proteins like Anandamide ( the Bliss molecule ) which activate happiness, calm, & reward emotions.
According to the Autism Research Institute, some of the symptoms that MMJ have improved include “anxiety, aggression, panic disorder, generalized rage, tantrums, property destruction, and self-injurious behavior.” Through cannabis/cannabiniods regulatory properties both of there own & through the EC system creating homeostasis, the body receives a calming experience through the process of homeostasis aiding in calm. as well as releasing curtain proteins like Anandamide ( the Bliss molecule ) which activate happiness, calm, & reward emotions.
According to the Autism Research Institute, some of the symptoms that MMJ have improved include “anxiety, aggression, panic disorder, generalized rage, tantrums, property destruction, and self-injurious behavior.”
Dr. Daniele Piomelli and Dr. Olivier Manzoni discovered that certain chemicals found in cannabis may help behavioral issues in children with autism or Fragile X syndrome.
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Dr. Jeff Bradley
Understanding the endocannabinoid System in Autism & It's Implications for Theraputics
Understanding the Endocannabinoid System in Autism & Its Implications for Therapeutics
Recent studies suggest abnormal cannabinoid receptor type 2 (CB2) signalling in peripheral blood mononuclear cells (PBMCs) extracted from autistic children, implying the endocannabinoid system could be functionally involved in ASD-mediated immune impairments. Cannabinoid 1 receptors are present on neurons and microglial cells and additional research implicates these receptors in neuronal protection in a way which may represent a therapeutic target in ASDs. Research will be presented.
Clinical Studies
Study - 2009. - Cannabiniod-induced apoptosis in immune cells as a pathway to immune suppression.
Study - 2014. - Marijuana shows potential in treating autoimmune disease
2006 - Study ~ DNA poly morphisms in the tetrahydrocannabinolic acid (THCA) synthase gene in "drug-type" and "fiber-type" Cannabis sativa L.
Patents
US6630507 Autoimmune Disorders; Cannabiniods as antioxidants & neuroprotectants
US6410588B1 1998-04-14 2002-06-25 anti-inflammatory agents The Mathilda And Terence Kennedy Institute Of Rheumatology Use of cannabinoids as anti-inflammatory agents
Study - 2014. - Marijuana shows potential in treating autoimmune disease
2006 - Study ~ DNA poly morphisms in the tetrahydrocannabinolic acid (THCA) synthase gene in "drug-type" and "fiber-type" Cannabis sativa L.
Patents
US6630507 Autoimmune Disorders; Cannabiniods as antioxidants & neuroprotectants
US6410588B1 1998-04-14 2002-06-25 anti-inflammatory agents The Mathilda And Terence Kennedy Institute Of Rheumatology Use of cannabinoids as anti-inflammatory agents