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Changing Medicine Together!
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~ Anxiety ~
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Preferred Strains
Note: CBD RICH Strains are Typically Best for Anxiety.
- Each Person is different (Best to try in smaller doses, to find Best Match for your Body Chemistry)!
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THC 17.0/22.0%
CBD 21.0/26.0% CBN 0.5/1.0% THC/CBD Ratio 80/20% Sativa Dominant |
THC 0.0/14.0%
CBD 0.0/23.4% CBN 0.0/0.O7% THC/CBD Ratio 1:2 Indica dominant |
THC 18.0/23.0%
CBD 0.03/0.2% CBN 0.0/0.03% THC/CBD Ratio Sativa Dominant |
THC 17.0/23.0%
CBD 0.1/0.2% CBN 0.01/0.05% THC/CBD Ratio Indica Dominant |
THC 0.42/1.20%
CBD 16.0/24.0% CBN 0.0/0.20% THC/CBD Ratio 1:20 |
Preferred Methods to Medicate
Note: when possible eat/drink raw kief/greens over & above the method to medicate, maximize Amino Acids & Cannabiniods like THCA, CBDA, etc, missing from modulation/decarboxylation.
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Allen I. Fankel, MD
Anxiety & Insomnia: Using Cannabis for Treatment GreenBridgeMedical.com |
Anxiety, Overview
Anxiety is an emotion characterized by an unpleasant state of inner turmoil, often accompanied by nervous behavior, such as pacing back and forth, somatic complaints, and rumination. It is the subjectively unpleasant feelings of dread over anticipated events, such as the feeling of imminent death. Anxiety is not the same as fear, which is a response to a real or perceived immediate threat, whereas anxiety is the expectation of future threat. Anxiety is a feeling of uneasiness and worry, usually generalized and unfocused as an overreaction to a situation that is only subjectively seen as menacing. It is often accompanied by muscular tension, restlessness, fatigue and problems in concentration. Anxiety can be appropriate, but when experienced regularly the individual may suffer from an anxiety disorder.
People facing anxiety may withdraw from situations which have provoked anxiety in the past. There are various types of anxiety. Existential anxiety can occur when a person faces angst, an existential crisis, or nihilistic feelings. People can also face mathematical anxiety, somatic anxiety, stage fright, or test anxiety. Social anxiety and stranger anxiety are caused when people are apprehensive around strangers or other people in general. Furthermore, anxiety has been linked with physical symptoms such as IBS and can heighten other mental health illnesses such as OCD and panic disorder. The first step in the management of a person with anxiety symptoms is to evaluate the possible presence of an underlying medical cause, whose recognition is essential in order to decide its correct treatment. Anxiety symptoms may be masking an organic disease, or appear associated or as a result of a medical disorder.
Anxiety can be either a short term "state" or a long term "trait". Whereas trait anxiety represents worrying about future events, anxiety disorders are a group of mental disorders characterized by feelings of anxiety and fear. Anxiety disorders are partly genetic but may also be due to drug use, including alcohol, caffeine, and benzodiazepines (which are often prescribed to treat anxiety), as well as withdrawal from drugs of abuse. They often occur with other mental disorders, particularly bipolar disorder, eating disorders, major depressive disorder, or certain personality disorders. Common treatment options include lifestyle changes, medication, and therapy
People facing anxiety may withdraw from situations which have provoked anxiety in the past. There are various types of anxiety. Existential anxiety can occur when a person faces angst, an existential crisis, or nihilistic feelings. People can also face mathematical anxiety, somatic anxiety, stage fright, or test anxiety. Social anxiety and stranger anxiety are caused when people are apprehensive around strangers or other people in general. Furthermore, anxiety has been linked with physical symptoms such as IBS and can heighten other mental health illnesses such as OCD and panic disorder. The first step in the management of a person with anxiety symptoms is to evaluate the possible presence of an underlying medical cause, whose recognition is essential in order to decide its correct treatment. Anxiety symptoms may be masking an organic disease, or appear associated or as a result of a medical disorder.
Anxiety can be either a short term "state" or a long term "trait". Whereas trait anxiety represents worrying about future events, anxiety disorders are a group of mental disorders characterized by feelings of anxiety and fear. Anxiety disorders are partly genetic but may also be due to drug use, including alcohol, caffeine, and benzodiazepines (which are often prescribed to treat anxiety), as well as withdrawal from drugs of abuse. They often occur with other mental disorders, particularly bipolar disorder, eating disorders, major depressive disorder, or certain personality disorders. Common treatment options include lifestyle changes, medication, and therapy
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The physiological symptoms of anxiety may include:
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Animated
THC, CBD, anxiety & paranoia |
Standard Medications
Medication is typically prescribed for anxiety and depression treatment. Studies indicate that the SSRI’s and tricyclic antidepressants are very effective treatments for depression and anxiety. For extreme circumstances where the patient is experiencing panic and high levels of anxiety., benzodiazepines may also be prescribed for up to 3 weeks. This is typically how long it takes for most antidepressants to take effect. It is suggested that alongside medication, patients receive therapy to talk out their issues with a professional. but always do your research as these standard forms of medication have SOME side affects.
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Medications for the Treatment of Anxiety and Depression
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Typical side effects of anxiety and depression medication
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How Cannabis Aids
Anandamide, The Bliss Molecule: is the bodies version of a cannabiniod. The molecule in chocolate that give the blissful feeling, Also Naturally produced in the body; Anandamide is an important neurotransmitter, that’s also considered to be the “body’s own THC.” In fact, as it’s a source of joy and happiness, activating in many cases including during meditation. Cannabis can help correct this clinical deficiency. (Anandamide consists of: Hydrogen, nitrogen, Oxygen,& Carbon.)
Anandamide: is received by both CB1 & 2 cannabiniod receptors
Ananda, Sanskrit: For Bliss
PhytoCannabiniods: are in some ways a simplified molecular version producing the same affects and more, keying into the same receptors. Cannabiniods consist of: Hydrogen, Oxygen, & Carbon. (The 3 elements of life ( 1 Less then Anandamide, Nitrogen ))
In conclusion: Cannabis over & above ALL the healing properties it possess helps Anxiety, stress, depression through the function of anandamide, introducing the bliss molecule Helps to alleviate the symptoms.
Anandamide: is received by both CB1 & 2 cannabiniod receptors
Ananda, Sanskrit: For Bliss
PhytoCannabiniods: are in some ways a simplified molecular version producing the same affects and more, keying into the same receptors. Cannabiniods consist of: Hydrogen, Oxygen, & Carbon. (The 3 elements of life ( 1 Less then Anandamide, Nitrogen ))
In conclusion: Cannabis over & above ALL the healing properties it possess helps Anxiety, stress, depression through the function of anandamide, introducing the bliss molecule Helps to alleviate the symptoms.
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Medical Cannabis Treatment of Anxiety
Anxiolytic Serotonin is an essential neurotransmitter involved in the regulation of mood, sleep, appetite and libido. In the central nervous system serotonin communicates with numerous receptors responsible for a variety of biological functions. The precise mechanism by which the endocannabinoid system modulates anxiety and |
depression is still being investagated, but CBD is postulated to act as an agonist to the 5HT1areceptor. Activation of the 5HT1a receptor is understood to modulate the release of serotonin in the brain. This hypothesis was confirmed in a study in which mice were pretreated with a 5HT1a antagonist, the antidepressant effects of CBD were absent. Further evidence of the role of 5HT1a is given by the observed similarities of CBD and isapirone (a 5HT1a partial agonist) in public speaking model.
Neuroprotection
Impairment of the hippocampal neurogenesis has been associated with the pathogenesis of anxiety disorders and depression. CBD is though to stimulate hippocampal neurogenesis a property absent in CB1 knockout mice. The researchers postulate that the mechanism is hence CB1 dependent, CBD is thought to reduce the efficiency of FAAH hence reduce anandamide reuptake; hence the CB1 receptor is activated. |
Homeostasis
CBD & The Endocannabiniod System Cannabiniods, not just a nutrient. |
Neurogenesis: Re-growing brain cells
In the mammalian brain, the CB1 receptor is one of the most abundant G protein–coupled receptors, accounting for most, if not all, of the centrally mediated effects of cannabinoids (5). both embryonic and adult hippocampal NS/PCs express CB1 receptors. The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs)
In the mammalian brain, the CB1 receptor is one of the most abundant G protein–coupled receptors, accounting for most, if not all, of the centrally mediated effects of cannabinoids (5). both embryonic and adult hippocampal NS/PCs express CB1 receptors. The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs)
Brazilian Researchers Investigate CBD and how it may alleviate symptoms of Anxiety In Humans
Recruiting 10 patients with diagnosed Social Anxiety Disorder, the research team began by doing an analysis of patient brains via functional neuroimaging. Taking a look at the amount of bloodflow within various sections of the brain, the researchers were able to note how this changed upon CBD oil treatment.
In the first session, half of the patients received an oral dose of 400 mg of cannabidiol (CBD). The other half of the patients received placebos. Reversing these roles in the 2nd session., this gave all patients the opportunity of being treated with CBD. The results indicated CBD reduced anxiety in patients with social anxiety disorder and they pointed out how this was related to its effects on activity in limbic and paralimbic brain areas. According to the results of the study, cannabidiol (CBD) was associated with a significant decrease in subjective anxiety. Cerebral bloodflow after CBD treatment indicated an anxiolitic (anti-anxiety) effect in the areas of the brain that manage emotions.
Recruiting 10 patients with diagnosed Social Anxiety Disorder, the research team began by doing an analysis of patient brains via functional neuroimaging. Taking a look at the amount of bloodflow within various sections of the brain, the researchers were able to note how this changed upon CBD oil treatment.
In the first session, half of the patients received an oral dose of 400 mg of cannabidiol (CBD). The other half of the patients received placebos. Reversing these roles in the 2nd session., this gave all patients the opportunity of being treated with CBD. The results indicated CBD reduced anxiety in patients with social anxiety disorder and they pointed out how this was related to its effects on activity in limbic and paralimbic brain areas. According to the results of the study, cannabidiol (CBD) was associated with a significant decrease in subjective anxiety. Cerebral bloodflow after CBD treatment indicated an anxiolitic (anti-anxiety) effect in the areas of the brain that manage emotions.
Clinical Studies
1990 - Study ~ Cannabinoid Receptor Localization in Brain.
1997 - Study ~ Brain Chemicals Mimic Marijuana.
2000 - Study ~ The Cannabinoid System and Cytokine Network.
2009 - Study ~ Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress.
2009 - Editorial ~ The Endocannabinoid System in the Brain: From Biology to Therapy.
2009 - Study ~ Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system.
1997 - Study ~ Brain Chemicals Mimic Marijuana.
2000 - Study ~ The Cannabinoid System and Cytokine Network.
2009 - Study ~ Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress.
2009 - Editorial ~ The Endocannabinoid System in the Brain: From Biology to Therapy.
2009 - Study ~ Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system.
Hampson et al., "Dual Effects of Anandamide on NMDA Receptor-Mediated Responses and Neurotransmission," Journal of Neurochemistry, Lippincott-Raven Publishers, 70(2):671-676 (1998).
2014, Study. Vanderbilt University. Multiple Mechanistically Distinct Modes of Endocannabiniods Mobilization at Central Amygdala glutamatergic Synapses.
2010 - Study ~ Motion Sickness, Stress and the Endocannabinoid System.
2005 - Study ~ Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear.
Patents
US6630507 Cannabiniods as antioxidants & neuroprotectants
For More Clinical Studies Check Out, For More Patents Check Out,
2014, Study. Vanderbilt University. Multiple Mechanistically Distinct Modes of Endocannabiniods Mobilization at Central Amygdala glutamatergic Synapses.
2010 - Study ~ Motion Sickness, Stress and the Endocannabinoid System.
2005 - Study ~ Enhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear.
Patents
US6630507 Cannabiniods as antioxidants & neuroprotectants
For More Clinical Studies Check Out, For More Patents Check Out,
