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Changing Medicine Together
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~ Obesity ~
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Preferred Strains:
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Preferred Methods to Medicate:
Raw Kief/Greens
Ideally one should be eating Raw Kief/Greens for the A molecule THCA, CBDA etc, Over and above the preferred method of medicating, each cannabinoid & Terpenes plays a roll in healing.
Medicating
Ideally one should be eating Raw Kief/Greens for the A molecule THCA, CBDA etc, Over and above the preferred method of medicating, each cannabinoid & Terpenes plays a roll in healing.
Medicating
- Drops/Oil Dropped under tongue for faster absorption (Soft membrane tissue).
- Sprays, if for internal best applied through nasal sprays for soft tissue. (If Issue is eye's or ear's, apply to correlation)
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++ Capsules Only + Under the Tongue + Under the Tongue ++ ++ |
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Obesity, Overview;
Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.[1] People are generally considered obese when their body mass index (BMI), a measurement obtained by dividing a person's weight by the square of the person's height, is over 30 kg/m2, with the range 25–30 kg/m2 defined as overweight.[1] Some East Asian countries use lower values.[8] Obesity increases the likelihood of various diseases and conditions, particularly cardiovascular diseases, type 2 diabetes, obstructive sleep apnea, certain types of cancer, osteoarthritis and depression.[2][3]
Obesity is most commonly caused by a combination of excessive food intake, lack of physical activity, and genetic susceptibility.[1][4] A few cases are caused primarily by genes, endocrine disorders, medications, or mental disorder.[9] The view that obese people eat little yet gain weight due to a slow metabolism is not generally supported.[10] On average, obese people have a greater energy expenditure than their normal counterparts due to the energy required to maintain an increased body mass.[10][11]
Obesity is most commonly caused by a combination of excessive food intake, lack of physical activity, and genetic susceptibility.[1][4] A few cases are caused primarily by genes, endocrine disorders, medications, or mental disorder.[9] The view that obese people eat little yet gain weight due to a slow metabolism is not generally supported.[10] On average, obese people have a greater energy expenditure than their normal counterparts due to the energy required to maintain an increased body mass.[10][11]
How Cannabis Aids:
Recent studies have provided evidence that the endocannabinoid (EC) system has very significant effects on energy balance and metabolism through the central control of appetite and by affecting peripheral metabolism. Endocannabinoids are endogenous phospholipid derivatives which bind and activate cannabinoid receptors type 1 and type 2 (CB1 and CB2 receptors). The CB1 receptor, a G-protein coupled receptor, is believed to be responsible for the majority of the central effects of endocannaboids on appetite. Chronic positive energy balance and obesity have been associated with an overactivation of the endocannaboid system which has been suggested to contribute to the development of abdominal obesity and to associated metabolic abnormalities which increase the risk of cardiovascular disease and type 2 diabetes. Animal studies had shown that stimulation of the cannabinoid CB1 receptor with endocannaboids such as anandamide could induce first an increase in food intake leading to body weight gain. Furthermore, an exciting development in this field has been the discovery of CB1 receptors in many peripheral tissues, including key organs involved in carbohydrate and lipid metabolism such as the adipose tissue and liver. Thus, blocking CB1 receptors located in the liver and adipose tissue could have an additional impact on the metabolic risk profile beyond what could be explained by the reduction in food intake and the related body weight loss. CB1R are also involved in eating behavior. CB1R knockout mice eat less than do wild types, and CB1R antagonists reduce the food intake in wild-type mice, but not in knockout mice (Di Marzo et al., 2001). CB1R antagonists and inverse agonists also suppress operant responding for food rewards (Cooper, 2004). In a 12-week study in mice with CB1R inverse agonist, taranabant, the animals lost weight over the entire range of tested doses (Addy et al., 2008). CB1R antagonists to aid weight loss are being developed in humans (Cota et al., 2003). The most advanced of such compounds is the inverse agonist, rimonabant, with which the reduction in body weight, waist circumference, and improved lipid and glucose metabolism in obese individuals has been observed (Vickers and Kennett, 2005). CB1R research may also help treat forms of anorexia. Restricting type AN and binging/purging type are associated with distinct alleles of the CNR1 gene (Siegfried et al., 2004). Preclinical studies have shown that rimonabant, the first CB1-receptor blocker to be available in clinical practice, could not only induce a reduction in food intake, but could also produce body weight loss beyond what could be explained by its effect on food intake. Thus, the evidence from preclinical studies have suggested that CB1 blockade could represent a relevant approach to reduce food intake, to induce body weight loss, and, most importantly, to "fix" the dysmetabolic state of viscerally obese patients at increased cardiometabolic risk.
Laboratory Studies
2000 - Study ~ Endogenous cannabinoids and appetite.
2003 - Study ~ Endogenous cannabinoid system as a modulator of food intake.
2003 - Study ~ The cannabinoid system: a role in both the homeostatic and hedonic control of eating?
2000 - Study ~ Endogenous cannabinoids and appetite.
2003 - Study ~ Endogenous cannabinoid system as a modulator of food intake.
2003 - Study ~ The cannabinoid system: a role in both the homeostatic and hedonic control of eating?
