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~ Neurological Disorder ~
Patents
US6630507 Autoimmune/Neurological Disorders; Cannabiniods as antioxidants & neuroprotectants
US6410588B1 1998-04-14 2002-06-25 anti-inflammatory agents The Mathilda And Terence Kennedy Institute Of Rheumatology Use of cannabinoids as anti-inflammatory agents
US6410588B1 1998-04-14 2002-06-25 anti-inflammatory agents The Mathilda And Terence Kennedy Institute Of Rheumatology Use of cannabinoids as anti-inflammatory agents
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Preferred Strains
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Preferred Methods to Medicate
Raw Kief/Greens
Ideally one should be eating Raw Kief/Greens for the A molecule THCA, CBDA etc, Over and above the preferred method of medicating, each cannabinoid & Terpenes plays a roll in healing.
Medicating
Ideally one should be eating Raw Kief/Greens for the A molecule THCA, CBDA etc, Over and above the preferred method of medicating, each cannabinoid & Terpenes plays a roll in healing.
Medicating
- Drops/Oil Dropped under tongue for faster absorption (Soft membrane tissue).
- Sprays, if for internal best applied through nasal sprays for soft tissue. (If Issue is eye's or ear's, apply to correlation)
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+ + + + + Topic app. is beneficial for local issue's ie, pain + + + + ++ |
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Neurological Disorder Overview:
A neurological disorder is any disorder of the nervous system. Structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves can result in a range of symptoms. Examples of symptoms include paralysis, muscle weakness, poor coordination, loss of sensation, seizures, confusion, pain and altered levels of consciousness. There are many recognized neurological disorders, some relatively common, but many rare. They may be assessed by neurological examination, and studied and treated within the specialities of neurology and clinical neuropsychology.
Although the brain and spinal cord are surrounded by tough membranes, enclosed in the bones of the skull and spinal vertebrae, and chemically isolated by the blood–brain barrier, they are very susceptible if compromised. Nerves tend to lie deep under the skin but can still become exposed to damage. Individual neurons, and the neural networks and nerves into which they form, are susceptible to electrochemical and structural disruption. Neuroregeneration may occur in the peripheral nervous system and thus overcome or work around injuries to some extent, but it is thought to be rare in the brain and spinal cord. Neuropsychiatric features of disorders are abnormalities in specific areas of higher brain function, including the limbic system, which controls feelings and emotions. Disorders can include attention deficit disorder, or ADD, dementia, epilepsy or some sort of head trauma. These disorders can have features such as depression, anxiety, irritability, memory impairment and psychosis. While genetics can play a role in each of these, having a B12 deficiency may also be a cause.
B12 helps your body use amino acids that power your brain. Not only is it essential for normal neurological function, it also works to synthesize DNA and RNA, the genetic material found in all cells.
Related to B12: Cannabis Especially Raw Kief/Cannabis/Greens are loaded with all Amino Acids plus 4 newly discovered Acids, as well cannabis is a mineral enhancer, rejuvenator, transporter, synthesization properties, gene transcript modulation properties, directly aiding in the disorders and in the potential B12 deficiency.
Neurological Classifications
Neurological disorders can be categorized according to the primary location affected, the primary type of dysfunction involved, or the primary type of cause. The broadest division is between central nervous system disorders and peripheral nervous system disorders. The Merck Manual lists brain, spinal cord and nerve disorders in the following overlapping categories:[3
- Brain:
- Brain damage according to cerebral lobe (see also 'lower' brain areas such as basal ganglia, cerebellum, brainstem):
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- Spinal cord disorders (see spinal pathology, injury, inflammation)
- Peripheral neuropathy and other Peripheral nervous system disorders
- Cranial nerve disorder such as Trigeminal neuralgia
- Autonomic nervous system disorders such as dysautonomia, Multiple System Atrophy
- Seizure disorders such as epilepsy
- Movement disorders of the central and peripheral nervous system such as Parkinson's disease, Essential tremor, Amyotrophic lateral sclerosis, Tourette's Syndrome, Multiple Sclerosis and various types of Peripheral Neuropathy
- Sleep disorders such as Narcolepsy
- Migraines and other types of Headache such as Cluster Headache and Tension Headache
- Lower back and neck pain (see Back pain)
- Central neuropathy (see Neuropathic pain)
- Neuropsychiatric illnesses (diseases and/or disorders with psychiatric features associated with known nervous system injury, underdevelopment, biochemical, anatomical, or electrical malfunction, and/or disease pathology e.g. Attention deficit hyperactivity disorder, Autism, Tourette's syndrome and some cases of obsessive compulsive disorder as well as the neurobehavioral associated symptoms of degeneratives of the nervous system such as Parkinson's disease, essential tremor, Huntington's disease, Alzheimer's disease, multiple sclerosis and organic psychosis.)
~ How Cannabis Aids ~
Neuro Expression & gene Transcription:
Endogenous cannabinoid (eg. THC, CBD) ligand interaction with cannabinoid type 1 receptor regulates expression of genes involved in long-term depression. Cannabinoid type 1 receptor (CB1R) is highly expressed in the cortex, substantia nigra pars reticulata, globus pallidus, cerebellum, hippocampus, and brainstem, thereby modulating a wide range of neural functions, making the activation of the type 1 receptors directly aid in the areas in question for PD, Autism, bipolar, MS, Tourette's, etc (Autoimmune, Neurological, movement disorders). such as motor activity, learning, and memory. CB1R, located presynaptically on GABA and glutamate neurons, decreases their release by inhibition of presynaptic Ca2+ influx through voltage-gated Ca2+ channels (VGCCs). CB1R activation is coupled with inhibition of adenylyl cyclase, downregulation of the cAMP/PKA pathway, and activation of the MAP kinase/ERK pathway, thereby regulating expression of genes through gene modulation transcription, recoding the potentially missing coded genetic script. eCBs are the best characterized retrograde messenger for carrying out neurological actions of endocannabinoids.which is a beneficial property for those with PD, Tourette's, Epilepsy etc. Formation of 2-arachidonoylglycerol (2-AG) occurs through the influx of Ca2+ via VGCCs and by activating the enzyme phospholipase Cb (PLCb), which triggers short and long term plasticity aiding in the repair of damaged neurons, common within a neuropsychiatric disorder (Hashimotodani et al., 2007). eCBs interaction with CB1R is capable of inducing presynapsis forms (eCB-LTD) at both excitatory and inhibitory synapses. Marijuana alters eCB levels, resulting in the rejuvenation of memory and learning.
Regulatory proteins, Neuroadaptive & Pathogenesis
( eg. Anandamide, 2-AG, THC, CBD, CBC, THCA, THCV, etc ) play a role in controlling cannabinoid signaling via CB1 & 2 receptors which plays a role/regulates most Systems and organs(reviewed in Ref. [37]). The cannabinoid receptor-interacting proteins 1a and 1b (CRIP1a and CRIP1b) are only known to interact with CB1 receptors. Both CRIP1a and CRIP1b directly interact with the C-terminus of the CB1 receptor but not CB2. More clinical studies are needed on the regulation and function of these interacting proteins. Evidence suggests that CRIP1a attenuates CB1 receptor-induced inhibition of Ca2+efflux.37,38 CRIP1a, like CB1, is widely expressed in the brain at high levels.38 It has been suggested that these regulatory proteins play a critical role in modulating CB1 receptor function in the pathogenesis or neuroadaptive response to epilepsy, PD, And other Autoimmune, & neurological/psychiatric disorders. There are a number of other regulatory proteins that interact with CB1 to affect signal transduction. Some of these are nonspecific G-protein receptors regulators such as G-protein-coupled receptor kinase-3 (GRK3) and β-arrestin2. These proteins facilitate desensitization and intracellular trafficking of CB1 receptors.39,40 Other regulatory proteins including AP3 and G protein receptor associated sorting protein-1 (GASP1) associate with CB1 and limited number of other G-coupled receptors. These proteins are less promiscuous and associate with only a limited subset of G-coupled receptors. They direct CB1 targeting to lysosomes,41,42 a mechanism of downregulation of response.
( eg. Anandamide, 2-AG, THC, CBD, CBC, THCA, THCV, etc ) play a role in controlling cannabinoid signaling via CB1 & 2 receptors which plays a role/regulates most Systems and organs(reviewed in Ref. [37]). The cannabinoid receptor-interacting proteins 1a and 1b (CRIP1a and CRIP1b) are only known to interact with CB1 receptors. Both CRIP1a and CRIP1b directly interact with the C-terminus of the CB1 receptor but not CB2. More clinical studies are needed on the regulation and function of these interacting proteins. Evidence suggests that CRIP1a attenuates CB1 receptor-induced inhibition of Ca2+efflux.37,38 CRIP1a, like CB1, is widely expressed in the brain at high levels.38 It has been suggested that these regulatory proteins play a critical role in modulating CB1 receptor function in the pathogenesis or neuroadaptive response to epilepsy, PD, And other Autoimmune, & neurological/psychiatric disorders. There are a number of other regulatory proteins that interact with CB1 to affect signal transduction. Some of these are nonspecific G-protein receptors regulators such as G-protein-coupled receptor kinase-3 (GRK3) and β-arrestin2. These proteins facilitate desensitization and intracellular trafficking of CB1 receptors.39,40 Other regulatory proteins including AP3 and G protein receptor associated sorting protein-1 (GASP1) associate with CB1 and limited number of other G-coupled receptors. These proteins are less promiscuous and associate with only a limited subset of G-coupled receptors. They direct CB1 targeting to lysosomes,41,42 a mechanism of downregulation of response.
Neuroplasticity & Neurogenesis
involves the sprouting and pruning of synapses,
changes in dendritic spine density, and changes in neurotransmitter pathways. It gives rise to all types of adaptive learning, including recovering from a stroke, the conscious act of gaining a new skill, and the unconscious acquisition of a new emotional response. It is also involved in pathological processes such as central sensitization to pain. There are multiple mechanisms by which cannabinoids modulate neural plasticity, including neurogenesis (the formation of new neurons), aiding in long-term potentiation and long-term depression. Research in humans has shown that the administration of exogenous cannabinoids can cause neuroplastic changes. Anandamide and 2-AG are also endogenous neuroprotective agents, produced by the nervous system in response to both chemical and mechanical trauma. Both phytocannabinoids ( Cannabis) and synthetic (GMO) cannabinoids have been shown to decrease glutamate excitotoxicity in a situation of a seizure or a stroke. (Although nature is always best. No side affects) When neurons become injured or ill, they tend to release their contents. Excitatory neurons release levels of glutamate that become toxic to the surrounding cells, and we see a domino effect of excitotoxicity. Cannabinoids have been shown to halt that process. The United States Department of Health and Human Services actually owns a patent on the use of cannabinoids as anti-oxidants and neuroprotectants. The authors of this patent discuss the potential benefit of using cannabinoids in neurodegenerative conditions such as Epilepsy, multiple sclerosis, Alzheimer’s, Parkinson’s, Huntington’s, and more. Cannabinoids also affect autonomic tone. In the sympathetic nervous system, CB1 receptor stimulation will inhibit noroepinephrine release. It will dampen sympathetically mediated pain and modulate the hypothalamic- pituitary-adrenal axis and the hypothalamic locus coerulius-norepinephrine axis.
involves the sprouting and pruning of synapses,
changes in dendritic spine density, and changes in neurotransmitter pathways. It gives rise to all types of adaptive learning, including recovering from a stroke, the conscious act of gaining a new skill, and the unconscious acquisition of a new emotional response. It is also involved in pathological processes such as central sensitization to pain. There are multiple mechanisms by which cannabinoids modulate neural plasticity, including neurogenesis (the formation of new neurons), aiding in long-term potentiation and long-term depression. Research in humans has shown that the administration of exogenous cannabinoids can cause neuroplastic changes. Anandamide and 2-AG are also endogenous neuroprotective agents, produced by the nervous system in response to both chemical and mechanical trauma. Both phytocannabinoids ( Cannabis) and synthetic (GMO) cannabinoids have been shown to decrease glutamate excitotoxicity in a situation of a seizure or a stroke. (Although nature is always best. No side affects) When neurons become injured or ill, they tend to release their contents. Excitatory neurons release levels of glutamate that become toxic to the surrounding cells, and we see a domino effect of excitotoxicity. Cannabinoids have been shown to halt that process. The United States Department of Health and Human Services actually owns a patent on the use of cannabinoids as anti-oxidants and neuroprotectants. The authors of this patent discuss the potential benefit of using cannabinoids in neurodegenerative conditions such as Epilepsy, multiple sclerosis, Alzheimer’s, Parkinson’s, Huntington’s, and more. Cannabinoids also affect autonomic tone. In the sympathetic nervous system, CB1 receptor stimulation will inhibit noroepinephrine release. It will dampen sympathetically mediated pain and modulate the hypothalamic- pituitary-adrenal axis and the hypothalamic locus coerulius-norepinephrine axis.
Decreased brain cell degeneration
Cannabis Aiding in Regeneration of brain & NS Cells ( And All Other Cells )
A buildup of neurotoxins that the body cannot eliminate is believed to contribute to Parkinson’s and many other neurological disorders. Studies have repeatedly found that cannabis aids cells in the elimination of toxins and other waste products. Ingested cannabinoids support and improve mitochondrial function, which is responsible for cellular respiration, the metabolizing of carbohydrates into energy, and the excretion of waste products. Cannabinoids have also been found to slow neurodegeneration, the leading cause of cell decay and cognitive function impairment among those living with Alzheimers, Parkinson’s & other ailments. Ontop of the neuroplasticity, neurogenesis, neuroprotective properties, cannabinoids/cannabis also aids directly in cellular functions with its autocrine, endocrine, & Paracrine properties Paracrine signaling is a form of cell-to-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome, in the case of cannabinoids and the antioxidative, anti-inflammatory transporter, Enhancing properties and much more cannabinoids create homeostasis in the cellular system.
cannabinoids couple to the PPAR receptors which are functional cellular nuclei receptors, promoting homeostasis from the cellular level right up through to the neuro network.
Cannabis Aiding in Regeneration of brain & NS Cells ( And All Other Cells )
A buildup of neurotoxins that the body cannot eliminate is believed to contribute to Parkinson’s and many other neurological disorders. Studies have repeatedly found that cannabis aids cells in the elimination of toxins and other waste products. Ingested cannabinoids support and improve mitochondrial function, which is responsible for cellular respiration, the metabolizing of carbohydrates into energy, and the excretion of waste products. Cannabinoids have also been found to slow neurodegeneration, the leading cause of cell decay and cognitive function impairment among those living with Alzheimers, Parkinson’s & other ailments. Ontop of the neuroplasticity, neurogenesis, neuroprotective properties, cannabinoids/cannabis also aids directly in cellular functions with its autocrine, endocrine, & Paracrine properties Paracrine signaling is a form of cell-to-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome, in the case of cannabinoids and the antioxidative, anti-inflammatory transporter, Enhancing properties and much more cannabinoids create homeostasis in the cellular system.
cannabinoids couple to the PPAR receptors which are functional cellular nuclei receptors, promoting homeostasis from the cellular level right up through to the neuro network.
(-) Ion Channels, Nervous system,
There are two type of Ion Channels both of which are regulated by the Endo-cannabinoid system Voltagegated Ion Channels and the Ligand-gated ion channels which are both a form of regulatory systems themselves. Ligand-gated Ion Channel such as the nicotinic acetylcholine receptor and GABAA receptor are composed of five subunits arranged around a central pore that opens to allow ions to pass through, to the Nervous system ( essentially charging up the nervous system & more) There are many different subunits available that can come together in a wide variety of combinations to form different subtypes of the ion channel called heteromer. These Ion channels are directly linked to the nervous system and both are regulated by the endo-cannabinoid system to facilitating homeostasis/balance throughout the bodily functions, thus when there is an imbalance in the nervous system, brain or pathways to and from, supplementing cannabinoids has shown to kick start the process of homeostasis throughout As cannabinoids have a regular bodily function, ready on demand for neuro synapse, in which a synaptic neurone loses it's polarity a signal is received by the endocannabinoid system, causing anandamide ( Cannabinoid ) to be released to that particular neurone to re-polarize it's charge. Through a Slightly similar function the cannabinoid system regulates the Voltagegated Ion Channels, through the function of the cannabinoid system, the cannabinoid couples to the G protein through the G receptor which inturn configures the cannabinoid protein the right configuration to fit the Ion receptors, allowing cannabinoids (healing/regulatory) Properties to create homeostasis. Voltage-gated ion channels are a class of transmembrane proteins that form ion channels that are activated by changes in the electrical membrane potential signalled by the Endo-cannabinod system near the channel. The membrane potential alters the conformation of the channel proteins, regulating their opening and closing. Cell membranes are generally impermeable to ions, thus they must diffuse through the membrane through transmembrane protein channels. They have a crucial role in excitable cells such as neuronal and muscle tissues, allowing a rapid and co-ordinated depolarization in response to triggering voltage change. Found along the axon and at the synapse, voltage-gated ion channels directionally propagate electrical signals (ie the electrical/magnetic charge pushes the signal/peptide/proteins up or down the axon/neuron/glial pathways) A Little re-dundance, cannabinoids re-polarize depolarized synaptic neurons, as, well regulates the ion channels which repolarizes synaptic neurones. Cannabinoids enhance, and transport, ion channels are the main transporter function which is regulated by the enhancer, transporting cannabinoid & Cannabinoid system.
(Ions Are electrical discharge from "X"/everything/ anything, ions a essential aspect to health at many levels, everything healthy like: a shower/waterfalls, to a apple, or nature are all (-) Ions, all harmful catagories, are (+) Ions eg. cellphones, power lines, computer etc. Absorb through the pores transported through to the nervous system to be synthesised.)
(Ions Are electrical discharge from "X"/everything/ anything, ions a essential aspect to health at many levels, everything healthy like: a shower/waterfalls, to a apple, or nature are all (-) Ions, all harmful catagories, are (+) Ions eg. cellphones, power lines, computer etc. Absorb through the pores transported through to the nervous system to be synthesised.)
Clinical Studies
Study - -biomarkers for drugs of abuse and neuropsychiatric disordersPushpinder Kaur Multani, ... Praveen Sharma, in Biomarkers in Toxicology, 2014
2014 - Study ~ Trans-Caryophyllene Suppresses Hypoxia-Induced Neuroinflammatory Responses by Inhibiting NF-κB Activation in Microglia.
2013 - Study ~ Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma
2013 - Study ~ The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties.
2013 - Study ~ The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain
2013 - Study ~ Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis
2013 - Study ~ Cannabinoid receptor modulation of the endothelial cell inflammatory response
2013 - Study ~ Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors.
2013 - Study ~ Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy.
2013 - Study ~ Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors
2013 - Study ~ Selective Activation of Cannabinoid Receptor 2 in Leukocytes Suppresses Their Engagement of the Brain Endothelium and Protects the Blood-Brain Barrier.
2013 - Study ~ The Influence of Cannabinoids on Generic Traits of Neurodegeneration.
2013 - Study ~ Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model.
2013 - News ~ Sending multiple sclerosis up in smoke
2013 - News ~ Marijuana's Memory Paradox
2012 - Study ~ Prolonged oral Cannabinoid Administration prevents Neuroinflammation, lowers beta-amyloid Levels and improves Cognitive Performance in Tg APP 2576 Mice.
2012 - Study ~ The endocannabinoid system: a revolving plate in neuro-immune interaction in health and disease.
2012 - Study ~ Cannabinoid signalling regulates inflammation and energy balance: The importance of the brain-gut axis.
2012 - Study ~ The Role of Cannabinoids In Inflammatory Modulation of Allergic Respiratory Disorders, Inflammatory Pain and Ischemic Stroke.
2012 - Study ~ Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?
2012 - Study ~ Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.
2012 - Study ~ Differential Modulation by Delta(9)-Tetrahydrocannabinol (∆ (9)-THC) of CD40 Ligand (CD40L) Expression in Activated Mouse Splenic CD4(+) T cells.
2011 - Study ~ Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement.
2011 - Study ~ Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa.
2011 - Study ~ Gut feelings about the endocannabinoid system.
2011 - Study ~ Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis.
2011 - Study ~ Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation.
2011 - Study ~ Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ(9) -tetrahydrocannabinol in BV-2 microglial cells.
2011 - Study ~ Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death.
2011 - News ~ New metabolic pathway for controlling brain inflammation.
2010 - Study ~ The endocannabinoid system as a target for the treatment of neurodegenerative disease.
2009 - Study - Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats.
2009 - Study ~ Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects.
2009 - Study ~ Cannabinoids Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells.
2009 - Study ~ Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4.
2009 - Study ~ Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease.
2009 - Study ~ Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death.
2009 - Study ~ Cannabinoids as novel anti-inflammatory drugs.
2009 - Study ~ The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function.
2009 - Study ~ Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis.
2008 - Study - Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders.
2008 - Study ~ Anti-inflammatory cannabinoids in diet.
2008 - Study ~ Cannabinoid receptors in acute and chronic complications of atherosclerosis.
2008 - Study ~ Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats.
2008- Study ~ Cannabinoid Modulation of Cutaneous A{delta} Nociceptors During Inflammation.
2008 - Study ~ Scientists are High on Idea that Cannabis Reduces Memory Impairment.
2008 - News - Marijuana reduces memory impairment.
2007 - Study ~ Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain
2007 - Study ~ Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis
2007 - Study ~ Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression (Alzheimer's)
2007 - Study ~ The endocannabinoid system in targeting inflammatory neurodegenerative diseases
2007 - Study ~ Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain
2007 - Study ~ Cannabinoids and neuroprotection in motor-related disorders.
2007 - News ~ Constituents Of Hashish And Marijuana May Help To Fight Inflammation And Allergies
2007 - News ~ Pot Chemical May Curb Inflammation
2007 - News ~ Endocannabinoids appear to play important role in regulating inflammation
2007 - News ~ Hippies vindicated: Human-produced cannabinoids have anti-inflammatory powers
2006 - Study ~ Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes
2006 - Study ~ The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells.
2006 - Study ~ Cannabinoid-Induced Immune Suppression and Modulation of Antigen-Presenting Cells
2006 - News ~ Anandamide, an endocannabinoid, protects neurons from inflammation after brain damage
2005 - Study ~ Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease.
2000 - Study ~ Endocannabinoids and fatty acid amides in cancer, inflammation and related disorders.
1999 - Study ~ 1′,1′-Dimethylheptyl-Δ-8-tetrahydrocannabinol-11-oic Acid: A Novel, Orally Effective Cannabinoid with Analgesic and Anti-inflammatory Properties.
1988 - Study - Analgestic and anti-inflammatory activity of constittuents of cannabis sativa L.
2014 - Study ~ Trans-Caryophyllene Suppresses Hypoxia-Induced Neuroinflammatory Responses by Inhibiting NF-κB Activation in Microglia.
2013 - Study ~ Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma
2013 - Study ~ The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties.
2013 - Study ~ The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain
2013 - Study ~ Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis
2013 - Study ~ Cannabinoid receptor modulation of the endothelial cell inflammatory response
2013 - Study ~ Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors.
2013 - Study ~ Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy.
2013 - Study ~ Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors
2013 - Study ~ Selective Activation of Cannabinoid Receptor 2 in Leukocytes Suppresses Their Engagement of the Brain Endothelium and Protects the Blood-Brain Barrier.
2013 - Study ~ The Influence of Cannabinoids on Generic Traits of Neurodegeneration.
2013 - Study ~ Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model.
2013 - News ~ Sending multiple sclerosis up in smoke
2013 - News ~ Marijuana's Memory Paradox
2012 - Study ~ Prolonged oral Cannabinoid Administration prevents Neuroinflammation, lowers beta-amyloid Levels and improves Cognitive Performance in Tg APP 2576 Mice.
2012 - Study ~ The endocannabinoid system: a revolving plate in neuro-immune interaction in health and disease.
2012 - Study ~ Cannabinoid signalling regulates inflammation and energy balance: The importance of the brain-gut axis.
2012 - Study ~ The Role of Cannabinoids In Inflammatory Modulation of Allergic Respiratory Disorders, Inflammatory Pain and Ischemic Stroke.
2012 - Study ~ Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?
2012 - Study ~ Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.
2012 - Study ~ Differential Modulation by Delta(9)-Tetrahydrocannabinol (∆ (9)-THC) of CD40 Ligand (CD40L) Expression in Activated Mouse Splenic CD4(+) T cells.
2011 - Study ~ Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement.
2011 - Study ~ Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa.
2011 - Study ~ Gut feelings about the endocannabinoid system.
2011 - Study ~ Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis.
2011 - Study ~ Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation.
2011 - Study ~ Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ(9) -tetrahydrocannabinol in BV-2 microglial cells.
2011 - Study ~ Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death.
2011 - News ~ New metabolic pathway for controlling brain inflammation.
2010 - Study ~ The endocannabinoid system as a target for the treatment of neurodegenerative disease.
2009 - Study - Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats.
2009 - Study ~ Emerging Role of the CB2 Cannabinoid Receptor in Immune Regulation and Therapeutic Prospects.
2009 - Study ~ Cannabinoids Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells.
2009 - Study ~ Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4.
2009 - Study ~ Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease.
2009 - Study ~ Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death.
2009 - Study ~ Cannabinoids as novel anti-inflammatory drugs.
2009 - Study ~ The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function.
2009 - Study ~ Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis.
2008 - Study - Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders.
2008 - Study ~ Anti-inflammatory cannabinoids in diet.
2008 - Study ~ Cannabinoid receptors in acute and chronic complications of atherosclerosis.
2008 - Study ~ Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats.
2008- Study ~ Cannabinoid Modulation of Cutaneous A{delta} Nociceptors During Inflammation.
2008 - Study ~ Scientists are High on Idea that Cannabis Reduces Memory Impairment.
2008 - News - Marijuana reduces memory impairment.
2007 - Study ~ Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain
2007 - Study ~ Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis
2007 - Study ~ Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression (Alzheimer's)
2007 - Study ~ The endocannabinoid system in targeting inflammatory neurodegenerative diseases
2007 - Study ~ Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain
2007 - Study ~ Cannabinoids and neuroprotection in motor-related disorders.
2007 - News ~ Constituents Of Hashish And Marijuana May Help To Fight Inflammation And Allergies
2007 - News ~ Pot Chemical May Curb Inflammation
2007 - News ~ Endocannabinoids appear to play important role in regulating inflammation
2007 - News ~ Hippies vindicated: Human-produced cannabinoids have anti-inflammatory powers
2006 - Study ~ Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes
2006 - Study ~ The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells.
2006 - Study ~ Cannabinoid-Induced Immune Suppression and Modulation of Antigen-Presenting Cells
2006 - News ~ Anandamide, an endocannabinoid, protects neurons from inflammation after brain damage
2005 - Study ~ Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease.
2000 - Study ~ Endocannabinoids and fatty acid amides in cancer, inflammation and related disorders.
1999 - Study ~ 1′,1′-Dimethylheptyl-Δ-8-tetrahydrocannabinol-11-oic Acid: A Novel, Orally Effective Cannabinoid with Analgesic and Anti-inflammatory Properties.
1988 - Study - Analgestic and anti-inflammatory activity of constittuents of cannabis sativa L.
Patents
1989 ~ Antiinflammatory and antimicrobial compounds and compositions
United States Patent 4837228.
US6630507 Autoimmune/Neurological Disorders; Cannabiniods as antioxidants & neuroprotectants
US6410588B1 1998-04-14 2002-06-25 anti-inflammatory agents The Mathilda And Terence Kennedy Institute Of Rheumatology Use of cannabinoids as anti-inflammatory agents
United States Patent 4837228.
US6630507 Autoimmune/Neurological Disorders; Cannabiniods as antioxidants & neuroprotectants
US6410588B1 1998-04-14 2002-06-25 anti-inflammatory agents The Mathilda And Terence Kennedy Institute Of Rheumatology Use of cannabinoids as anti-inflammatory agents