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Changing Medicine Together
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~ Diabetes ~
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Note: Autoimmune Disorder, is responsible for over 100 diseases, from rheumatoid arthritis, lupus, type 1 diabetes, celiac, psoriasis, multiple sclerosis & on. There is clearly a link (hence the summarized title, Autoimmune) although the clear differences, eg. Arthritis, Lupus. This aspect makes it difficult for big Pharma to Band-Aid the problem. Studies show people with Autoimmune, have a increase of Cannabiniod receptors in curtain areas, suggesting the body is in need of more Cannabiniods. Research has discovered that endocannabinoids are immunomodulators.
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Although Cannabis does NOT cure all of the Autoimmune disorders, it is very beneficial in all cases, as the Endocannabiniod System regulates all major organs and functioning bodily systems, eg. Immune, Nervous, Digestive, Lymph, etc. It Promotes Homeostasis throughout the body.
Cannabis has Regenerative functionalities ( in cells, neurons, muscle, vitamins, minerals, bone, etc), Assists in vitamin transport, enhancement, & synthesis, cannabis Activates the appropriate proteins & enzymes the body requires, all the while supressing the harmful proteins & enzymes, it Produces H2O2 |
which produces oxygen, and even decalcifies/plaque dissolving. With all these properties & much more, with no adverse side affects Cannabis is clearly the safe and beneficial treatment.
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Preferred Methods to Medicate:
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+ + + + Under the Tongue + Under the Tongue + |
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Fox News
Cure For Diabetes (Type 1 & 2) Washington University School of Medicine Dr. Marc Hammerman, Detailed in the American Journal of pathology. Marc is pump up with the latest findings! |
CBD Wellness Guide
CBD In the Treatment of Diabetes Diabetes & Cannabis 101 Animated: A clear General Break Down of how cannabis treats type 1 & 2 |
Diabetes, Overview:
Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period.[7]
Symptoms of high blood sugar include frequent urination, increased thirst, and increased hunger.[2]
If left untreated, diabetes can cause many complications.[2] Acute complications can include diabetic ketoacidosis, hyperosmolar hyperglycemic state, or death.[3] Serious long-term complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, and damage to the eyes.[2]
Diabetes is due to either the pancreas not producing enough insulin or the cells of the body not responding properly to the insulin produced.[8] There are three main types of diabetes mellitus:[2]
Symptoms of high blood sugar include frequent urination, increased thirst, and increased hunger.[2]
If left untreated, diabetes can cause many complications.[2] Acute complications can include diabetic ketoacidosis, hyperosmolar hyperglycemic state, or death.[3] Serious long-term complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, and damage to the eyes.[2]
Diabetes is due to either the pancreas not producing enough insulin or the cells of the body not responding properly to the insulin produced.[8] There are three main types of diabetes mellitus:[2]
- Type 1 DM results from the pancreas's failure to produce enough insulin.[2] This form was previously referred to as "insulin-dependent diabetes mellitus" (IDDM) or "juvenile diabetes".[2] The cause is unknown.[2]
- Type 2 DM begins with insulin resistance, a condition in which cells fail to respond to insulin properly.[2] As the disease progresses a lack of insulin may also develop.[9] This form was previously referred to as "non insulin-dependent diabetes mellitus" (NIDDM) or "adult-onset diabetes".[2] The most common cause is excessive body weight and insufficient exercise.[2]
- Gestational diabetes is the third main form, and occurs when pregnant women without a previous history of diabetes develop high blood sugar levels.[2]
How Cannabis Aids:
Note: New studies found that THCA stood out from CBD and cannabigiol (CBG) in positively affecting the PPARγ receptor in the brain, which regulates lipid metabolism and glucose homeostasis.
Insulin is the principal hormone that regulates the uptake of glucose from the blood into most cells of the body, especially liver, adipose tissue and muscle, except smooth muscle, in which insulin acts via the IGF-1. Therefore, deficiency of insulin or the insensitivity of its receptors play a central role in all forms of diabetes mellitus. Cannabis aids in facilating the regulation of hormones & treats Diabetes in several process's including,
- Cannabiniods are Neurotransmitters for the Endocannabiniod System. The ECS regulates all Physiopathological functions including hormones, which is one of the direct functions of Diabetes.
- Modulation of neurotransmitter release: Anandamide & Insulin
- Anandamide which has a important role in hormonal balance. Anandamide is a bodily endocannabiniod a version of THC a Phytocannabiniod. when low on Anandamide cannabis being molecularly/geometrically the same shape, Functioning through the same receptors, makes it a very efficient supplement with NO side affects.
- cannabis modulates Gene Transcription, (modulates change to gene coding) in this case changes to specific molecules called histones. Histones help control gene expression. The research found that THC can causes changes to histones in a way that suppresses inflammation. ( Inflammation is a major key in any autoimmune disorder ie. Diabetes (Type 1 more so).
- Cannabis Has ALL Amino Acids plus 4 newly identified amino acids. Amino Acids are the building blocks of life, All proteins hormones etc, are built from amino acids, giving the body the building blocks required to replenish the insulin/ glucose levels. even re activating production of Insulin.
- Cannabis has regenerative properties, for the function of insulin production through the cells or even through transmitters. as Cannabis is has regenerative properties & Neurogenesis, properties as well.
- Diabetes causes significant increases in retinal oxidative and nitrative stress compared with controls. These effects were associated with Müller cell activation and dysfunction as well as with impaired GS activity and tyrosine nitration of GS. Cannabidiol treatment reverses these effects.
More On Cannabis & Diabetes:
Type 1
Diabetes mellitus type 1Type 1 diabetes mellitus is characterized by loss of the insulin-producing beta cells of the pancreatic islets, leading to insulin deficiency. This type can be further classified as immune-mediated or idiopathic. The majority of type 1 diabetes is of the immune-mediated nature, in which a T cell-mediated autoimmune attack leads to the loss of beta cells and thus insulin.[34] It causes approximately 10% of diabetes mellitus cases in North America and Europe. Most affected people are otherwise healthy and of a healthy weight when onset occurs. Sensitivity and responsiveness to insulin are usually normal, especially in the early stages. Type 1 diabetes can affect children or adults, but was traditionally termed "juvenile diabetes" because a majority of these diabetes cases were in children.[citation needed]
"Brittle" diabetes, also known as unstable diabetes or labile diabetes, is a term that was traditionally used to describe the dramatic and recurrent swings in glucose levels, often occurring for no apparent reason in insulin-dependent diabetes. This term, however, has no biologic basis and should not be used.[35] Still, type 1 diabetes can be accompanied by irregular and unpredictable high blood sugar levels, frequently with ketosis, and sometimes with serious low blood sugar levels. Other complications include an impaired counterregulatory response to low blood sugar, infection, gastroparesis (which leads to erratic absorption of dietary carbohydrates), and endocrinopathies (e.g., Addison's disease).[35] These phenomena are believed to occur no more frequently than in 1% to 2% of persons with type 1 diabetes.[36]
Autoimmune attack in type 1 diabetes.
Type 1 diabetes is partly inherited, with multiple genes, including certain HLA genotypes, known to influence the risk of diabetes. In genetically susceptible people, the onset of diabetes can be triggered by one or more environmental factors,[37] such as a viral infection or diet. Several viruses have been implicated, but to date there is no stringent evidence to support this hypothesis in humans.[37][38] Among dietary factors, data suggest that gliadin (a protein present in gluten) may play a role in the development of type 1 diabetes, but the mechanism is not fully understood.[39][40]
Diabetes mellitus type 1Type 1 diabetes mellitus is characterized by loss of the insulin-producing beta cells of the pancreatic islets, leading to insulin deficiency. This type can be further classified as immune-mediated or idiopathic. The majority of type 1 diabetes is of the immune-mediated nature, in which a T cell-mediated autoimmune attack leads to the loss of beta cells and thus insulin.[34] It causes approximately 10% of diabetes mellitus cases in North America and Europe. Most affected people are otherwise healthy and of a healthy weight when onset occurs. Sensitivity and responsiveness to insulin are usually normal, especially in the early stages. Type 1 diabetes can affect children or adults, but was traditionally termed "juvenile diabetes" because a majority of these diabetes cases were in children.[citation needed]
"Brittle" diabetes, also known as unstable diabetes or labile diabetes, is a term that was traditionally used to describe the dramatic and recurrent swings in glucose levels, often occurring for no apparent reason in insulin-dependent diabetes. This term, however, has no biologic basis and should not be used.[35] Still, type 1 diabetes can be accompanied by irregular and unpredictable high blood sugar levels, frequently with ketosis, and sometimes with serious low blood sugar levels. Other complications include an impaired counterregulatory response to low blood sugar, infection, gastroparesis (which leads to erratic absorption of dietary carbohydrates), and endocrinopathies (e.g., Addison's disease).[35] These phenomena are believed to occur no more frequently than in 1% to 2% of persons with type 1 diabetes.[36]
Autoimmune attack in type 1 diabetes.
Type 1 diabetes is partly inherited, with multiple genes, including certain HLA genotypes, known to influence the risk of diabetes. In genetically susceptible people, the onset of diabetes can be triggered by one or more environmental factors,[37] such as a viral infection or diet. Several viruses have been implicated, but to date there is no stringent evidence to support this hypothesis in humans.[37][38] Among dietary factors, data suggest that gliadin (a protein present in gluten) may play a role in the development of type 1 diabetes, but the mechanism is not fully understood.[39][40]
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Cannabis & Type 1:
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Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases ( such as Rheumatoid Arthritis ). The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. THC (tetrahydrocannabinol) is another of the cannabinoids that has been shown to be neuroprotective in cell cultures, but this protection was believed to be mediated by interaction at the cannabinoid receptor. For Diabetic patients that may have issue's from both; the endocannabiniod system is a EC signalling system. This system participates in the control of lipid and glucose metabolism at several levels, starting at the genome level to the production of communication for proteins/hormones. Aiding, mimicking, transporting, protecting & enhancing, in the hole process.
Type 2
Diabetes mellitus type 2
Mechanism of insulin resistance in type 2 diabetes mellitus.
Type 2 DM is characterized by insulin resistance, which may be combined with relatively reduced insulin secretion.[8] The defective responsiveness of body tissues to insulin is believed to involve the insulin receptor. However, the specific defects are not known. Diabetes mellitus cases due to a known defect are classified separately. Type 2 DM is the most common type of diabetes mellitus.[2]
In the early stage of type 2, the predominant abnormality is reduced insulin sensitivity. At this stage, high blood sugar can be reversed by a variety of measures and medications that improve insulin sensitivity or reduce the liver's glucose production.
Type 2 DM is primarily due to lifestyle factors and genetics.[41] A number of lifestyle factors are known to be important to the development of type 2 DM, including obesity (defined by a body mass index of greater than 30), lack of physical activity, poor diet, stress, and urbanization.[13] Excess body fat is associated with 30% of cases in those of Chinese and Japanese descent, 60–80% of cases in those of European and African descent, and 100% of Pima Indians and Pacific Islanders.[8] Even those who are not obese often have a high waist–hip ratio.[8]
Dietary factors also influence the risk of developing type 2 DM. Consumption of sugar-sweetened drinks in excess is associated with an increased risk.[42][43] The type of fats in the diet is also important, with saturated fat and trans fats increasing the risk and polyunsaturated and monounsaturated fat decreasing the risk.[41] Eating lots of white rice also may increase the risk of diabetes.[44] A lack of physical activity is believed to cause 7% of cases.[45]
Diabetes mellitus type 2
Mechanism of insulin resistance in type 2 diabetes mellitus.
Type 2 DM is characterized by insulin resistance, which may be combined with relatively reduced insulin secretion.[8] The defective responsiveness of body tissues to insulin is believed to involve the insulin receptor. However, the specific defects are not known. Diabetes mellitus cases due to a known defect are classified separately. Type 2 DM is the most common type of diabetes mellitus.[2]
In the early stage of type 2, the predominant abnormality is reduced insulin sensitivity. At this stage, high blood sugar can be reversed by a variety of measures and medications that improve insulin sensitivity or reduce the liver's glucose production.
Type 2 DM is primarily due to lifestyle factors and genetics.[41] A number of lifestyle factors are known to be important to the development of type 2 DM, including obesity (defined by a body mass index of greater than 30), lack of physical activity, poor diet, stress, and urbanization.[13] Excess body fat is associated with 30% of cases in those of Chinese and Japanese descent, 60–80% of cases in those of European and African descent, and 100% of Pima Indians and Pacific Islanders.[8] Even those who are not obese often have a high waist–hip ratio.[8]
Dietary factors also influence the risk of developing type 2 DM. Consumption of sugar-sweetened drinks in excess is associated with an increased risk.[42][43] The type of fats in the diet is also important, with saturated fat and trans fats increasing the risk and polyunsaturated and monounsaturated fat decreasing the risk.[41] Eating lots of white rice also may increase the risk of diabetes.[44] A lack of physical activity is believed to cause 7% of cases.[45]
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How Cannabis Aids Type 2:
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Endocannabinoids (ECs) are defined as endogenous agonists of cannabinoid receptors type 1 and 2 (CB1 and CB2). ECs, EC anabolic and catabolic enzymes and cannabinoid receptors constitute the EC signalling system. This system participates in the control of lipid and glucose metabolism at several levels, with the possible endpoint of the accumulation of energy as fat. Following unbalanced energy intake, however, the EC system becomes dysregulated, and in most cases overactive, in several organs participating in energy homeostasis, particularly, in intra-abdominal adipose tissue. This dysregulation might contribute to excessive visceral fat accumulation and reduced adiponectin release from this tissue, and to the onset of several cardiometabolic risk factors that are associated with obesity and type 2 diabetes. This phenomenon might form the basis of the mechanism of action of CB1 antagonists/inverse agonists, recently developed by several pharmaceutical companies as adjuvants to lifestyle modification for weight reduction, glycaemic control and dyslipidaemia in obese and type 2 diabetes patients. It also helps to explain why some of the beneficial actions of these new therapeutics appear to be partly independent from weight loss. Cannabis not only mimics, it enhances, transports, actd as a neuro transmitter, modulates neurotransmition, aids in neurocommunication & as the ECS is a regulatory phisiopathological system it creates Homeostasis throughout the body. Therefore cannabis from our core(genes) balances and rewrites the scription, protects & helps the messaging system, and kick start the systems own insulin production or synthesis of the insulin
Gestational diabetes
Gestational diabetes
Gestational diabetes mellitus (GDM) resembles type 2 DM in several respects, involving a combination of relatively inadequate insulin secretion and responsiveness. It occurs in about 2–10% of all pregnancies and may improve or disappear after delivery.[46] However, after pregnancy approximately 5–10% of women with gestational diabetes are found to have diabetes mellitus, most commonly type 2.[46] Gestational diabetes is fully treatable, but requires careful medical supervision throughout the pregnancy. Management may include dietary changes, blood glucose monitoring, and in some cases, insulin may be required.
Though it may be transient, untreated gestational diabetes can damage the health of the fetus or mother. Risks to the baby include macrosomia (high birth weight), congenital heart and central nervous system abnormalities, and skeletal muscle malformations. Increased levels of insulin in a fetus's blood may inhibit fetal surfactant production and cause respiratory distress syndrome. A high blood bilirubin level may result from red blood cell destruction. In severe cases, perinatal death may occur, most commonly as a result of poor placental perfusion due to vascular impairment. Labor induction may be indicated with decreased placental function. A Caesarean section may be performed if there is marked fetal distress or an increased risk of injury associated with macrosomia, such as shoulder dystocia.
Gestational diabetes
Gestational diabetes mellitus (GDM) resembles type 2 DM in several respects, involving a combination of relatively inadequate insulin secretion and responsiveness. It occurs in about 2–10% of all pregnancies and may improve or disappear after delivery.[46] However, after pregnancy approximately 5–10% of women with gestational diabetes are found to have diabetes mellitus, most commonly type 2.[46] Gestational diabetes is fully treatable, but requires careful medical supervision throughout the pregnancy. Management may include dietary changes, blood glucose monitoring, and in some cases, insulin may be required.
Though it may be transient, untreated gestational diabetes can damage the health of the fetus or mother. Risks to the baby include macrosomia (high birth weight), congenital heart and central nervous system abnormalities, and skeletal muscle malformations. Increased levels of insulin in a fetus's blood may inhibit fetal surfactant production and cause respiratory distress syndrome. A high blood bilirubin level may result from red blood cell destruction. In severe cases, perinatal death may occur, most commonly as a result of poor placental perfusion due to vascular impairment. Labor induction may be indicated with decreased placental function. A Caesarean section may be performed if there is marked fetal distress or an increased risk of injury associated with macrosomia, such as shoulder dystocia.
How Cannabis Aids:
Gestational diabetes is a less sever diabetic issue if treated but the function of cannabis treating is as mentioned above. Consuming cannabis during pregnancy is safe and beneficial to both mother and child, with concern to moderation if smoking and awareness to body make up and strain preference. to utilize as a raw food is the best during pregnancy as the THC molecule is in-active, requiring heat to activate. raw cannabis/hemp is loaded with nutrients. For more on cannabis & pregnancy check out
Gestational diabetes is a less sever diabetic issue if treated but the function of cannabis treating is as mentioned above. Consuming cannabis during pregnancy is safe and beneficial to both mother and child, with concern to moderation if smoking and awareness to body make up and strain preference. to utilize as a raw food is the best during pregnancy as the THC molecule is in-active, requiring heat to activate. raw cannabis/hemp is loaded with nutrients. For more on cannabis & pregnancy check out
Other Types
Latent autoimmune diabetes of adults (LADA) is a condition in which type 1 DM develops in adults. Adults with LADA are frequently initially misdiagnosed as having type 2 DM, based on age rather than cause.
Other forms of diabetes mellitus include congenital diabetes, which is due to genetic defects of insulin secretion, cystic fibrosis-related diabetes, steroid diabetes induced by high doses of glucocorticoids, and several forms of monogenic diabetes.
"Type 3 diabetes" has been suggested as a term for Alzheimer's disease as the underlying processes may involve insulin resistance by the brain
Latent autoimmune diabetes of adults (LADA) is a condition in which type 1 DM develops in adults. Adults with LADA are frequently initially misdiagnosed as having type 2 DM, based on age rather than cause.
Other forms of diabetes mellitus include congenital diabetes, which is due to genetic defects of insulin secretion, cystic fibrosis-related diabetes, steroid diabetes induced by high doses of glucocorticoids, and several forms of monogenic diabetes.
"Type 3 diabetes" has been suggested as a term for Alzheimer's disease as the underlying processes may involve insulin resistance by the brain
The following is a comprehensive list of other causes of diabetes:[50]
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Pathophysiology:
Insulin is the principal hormone that regulates the uptake of glucose from the blood into most cells of the body, especially liver, adipose tissue and muscle, except smooth muscle, in which insulin acts via the IGF-1. Therefore, deficiency of insulin or the insensitivity of its receptors play a central role in all forms of diabetes mellitus
The body obtains glucose from three main sources: the intestinal absorption of food; the breakdown of glycogen, the storage form of glucose found in the liver; and gluconeogenesis, the generation of glucose from non-carbohydrate substrates in the body.[53] Insulin plays a critical role in balancing glucose levels in the body. Insulin can inhibit the breakdown of glycogen or the process of gluconeogenesis, it can stimulate the transport of glucose into fat and muscle cells, and it can stimulate the storage of glucose in the form of glycogen.[53]
Insulin is released into the blood by beta cells (β-cells), found in the islets of Langerhans in the pancreas, in response to rising levels of blood glucose, typically after eating. Insulin is used by about two-thirds of the body's cells to absorb glucose from the blood for use as fuel, for conversion to other needed molecules, or for storage. Lower glucose levels result in decreased insulin release from the beta cells and in the breakdown of glycogen to glucose. This process is mainly controlled by the hormone glucagon, which acts in the opposite manner to insulin.[54]
If the amount of insulin available is insufficient, or if cells respond poorly to the effects of insulin (insulin insensitivity or insulin resistance), or if the insulin itself is defective, then glucose will not be absorbed properly by the body cells that require it, and it will not be stored appropriately in the liver and muscles. The net effect is persistently high levels of blood glucose, poor protein synthesis, and other metabolic derangements, such as acidosis.[53]
When the glucose concentration in the blood remains high over time, the kidneys will reach a threshold of reabsorption, and glucose will be excreted in the urine (glycosuria).[55] This increases the osmotic pressure of the urine and inhibits reabsorption of water by the kidney, resulting in increased urine production (polyuria) and increased fluid loss. Lost blood volume will be replaced osmotically from water held in body cells and other body compartments, causing dehydration and increased thirst (polydipsia).[53]
The body obtains glucose from three main sources: the intestinal absorption of food; the breakdown of glycogen, the storage form of glucose found in the liver; and gluconeogenesis, the generation of glucose from non-carbohydrate substrates in the body.[53] Insulin plays a critical role in balancing glucose levels in the body. Insulin can inhibit the breakdown of glycogen or the process of gluconeogenesis, it can stimulate the transport of glucose into fat and muscle cells, and it can stimulate the storage of glucose in the form of glycogen.[53]
Insulin is released into the blood by beta cells (β-cells), found in the islets of Langerhans in the pancreas, in response to rising levels of blood glucose, typically after eating. Insulin is used by about two-thirds of the body's cells to absorb glucose from the blood for use as fuel, for conversion to other needed molecules, or for storage. Lower glucose levels result in decreased insulin release from the beta cells and in the breakdown of glycogen to glucose. This process is mainly controlled by the hormone glucagon, which acts in the opposite manner to insulin.[54]
If the amount of insulin available is insufficient, or if cells respond poorly to the effects of insulin (insulin insensitivity or insulin resistance), or if the insulin itself is defective, then glucose will not be absorbed properly by the body cells that require it, and it will not be stored appropriately in the liver and muscles. The net effect is persistently high levels of blood glucose, poor protein synthesis, and other metabolic derangements, such as acidosis.[53]
When the glucose concentration in the blood remains high over time, the kidneys will reach a threshold of reabsorption, and glucose will be excreted in the urine (glycosuria).[55] This increases the osmotic pressure of the urine and inhibits reabsorption of water by the kidney, resulting in increased urine production (polyuria) and increased fluid loss. Lost blood volume will be replaced osmotically from water held in body cells and other body compartments, causing dehydration and increased thirst (polydipsia).[53]
Clinical Studies
Study - 2007 - Cannabidiol arrests onset of autoimmune diabetes in NOD mice.
Study - 2010. - Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes
Study - 2013, - The American Journal of Medicine -
The Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance among US Adults
Study - group collaboration: Cannabis modulating a range of physiopathological process
Study - 2010. - Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes
Study - 2013, - The American Journal of Medicine -
The Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance among US Adults
Study - group collaboration: Cannabis modulating a range of physiopathological process