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Changing Medicine Together
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~ Cannabis, Female Reproductive ~ Health & Pregnancy
Cannabinoids are also heavily involved in embryology and cell growth and differentiation.
CB1 receptors have been detected in mouse embryos as early as the second day of gestation. Blastocyst implantation into the endometrium, which is thought of as the first suckling function, requires suitable levels of the bodily Cannabiniod, anandamide, or the phytocannabiniod is a perfect mimicker of anandamide. The proliferation and differentiation of neural stem cells are shaped by extracellular cues provided by endocannabinoids. Adult neurogenesis is regulated by many of these same embryonic endocannabinoid mechanisms.
CB1 receptors have been detected in mouse embryos as early as the second day of gestation. Blastocyst implantation into the endometrium, which is thought of as the first suckling function, requires suitable levels of the bodily Cannabiniod, anandamide, or the phytocannabiniod is a perfect mimicker of anandamide. The proliferation and differentiation of neural stem cells are shaped by extracellular cues provided by endocannabinoids. Adult neurogenesis is regulated by many of these same embryonic endocannabinoid mechanisms.
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~ Cannabis Nutrition ~
Dr. William Courtney
A Dietician's Perspective on Cannabis "Cannabis can save the world." "A bold statement perhaps, but potentially true nonetheless. As a dietitian, when I look at the cannabis plant, I first see its nutritional value as a vegetable, loaded with vitamins, minerals, and antioxidants. I also know that essentially cannabis is hemp, and hemp hits a home run every time when it comes to nutritional value (among its other thousands of industrial uses). As a holistic healthcare professional, I recognize and highly respect the diversity of cannabis in its uses as a medicine to heal and repair both the body and the mind. It is my opinion that cannabis may not only be the best medicine, but also the most nutritious plant known to humankind thus far." |
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~ Per 100 grams or Approx. a 1/2 cup of cannabis/Kief/seeds ~
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Calories
- From Carbohydrates - 3.0 (12.6 kJ) - From Fat - 127 (532 kJ) - From Protein - 44.0 (184 kJ) - Calories - 174 (729 kJ) |
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Cannabis/Hemp oils Fatty Acid Composition
Per Cannabis Plant/Seeds, Oil Comprises of Approx. 35% of the Total Weight
Unsaturated Fats: Stearidonic Acid, Oleic Acid, & Eicosaenoic Acid Saturated fats: Palmitic Acid, Steric Acid, Arachidic Acid. |
Breakdown of nutritional properties
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Cannabis/Hemp has the most amount of Essential Fatty Acids. Flax seed comes in 2nd at 72% combined total Essential Fatty Acids
Women and cannabis are entangled in a long, complicated, and largely forgotten history.
Curious?
Curious?
Cannabis has been used as a Women's Aid for Millenia
From easing pain on wedding nights to calming teething children, the cannabis plant has been used as a women’s aid for millennia.
The herb was a popular choice among ladies in many ancient cultures for relief from menstrual and reproductive disorders.
Historical medical texts from ninth century Persia provide an example, where it is thought that juice from cannabis seeds were used to prevent miscarriages, maintain pregnancy, calm pains, and ease migraine.
The most common medication for labor pain is an epidural.
Epidurals are injections that decrease sensation in the lower half of the body.
They are frequently administered with opioid pain medications and other narcotic drugs to ease the pains of labor.
Prior to the invention of modern medicine, however, our human ancestors had a different remedy: cannabis.
Cannabis was a major treatment for labor pains and the facilitation of childbirth for thousands of years.
Cannabis as a labor-aid was not unique to a single region.
Rather, many different societies in various parts of the world used the herb for this purpose.
These include Middle Eastern, Islamic, Egyptian, East Asian, Southeast Asian, South African, societies.
Epidurals are injections that decrease sensation in the lower half of the body.
They are frequently administered with opioid pain medications and other narcotic drugs to ease the pains of labor.
Prior to the invention of modern medicine, however, our human ancestors had a different remedy: cannabis.
Cannabis was a major treatment for labor pains and the facilitation of childbirth for thousands of years.
Cannabis as a labor-aid was not unique to a single region.
Rather, many different societies in various parts of the world used the herb for this purpose.
These include Middle Eastern, Islamic, Egyptian, East Asian, Southeast Asian, South African, societies.
Introduction/ Warm Up
Cannabis use during pregnancy is beneficial, for a mother in need (((When smoked) with knowledgeable moderate use ( as smoking to much may cause what they call a green out Tinctures, patches avoid that worry (everything in moderation/balance/homeostasis which, Ironically cannabis, through the endocannabiniod system Facilitates, throughout the entire body))), as there is cannabiniod receptors CB 1 & CB 2, throughout the brain & nervous system, all pathophysiological processes, Immune system, Reproductive, Endocrine (Hormone) System, Lymph system, Appetite & Digestive System, etc, & all major organs. The human body naturally produces its own cannabis-like compounds, two of which are Anandamide AEA ( the bliss molecule ), & 2-AG, ( these compounds are called endocannabiniods named after cannabis ). Cannabis mimics our own but in a simpler molecular form and a lot more healing properties. Every molecule of Cannabis regardless of variable ( strain or type of cannabiniod ie. THC, CBD, CBC, etc ) consists of only Hydrogen, Oxygen & Carbon, the 3 elements responsible for all of life, Curious?
These compounds are called cannabinoids, also named after cannabis.
These compounds are called cannabinoids, also named after cannabis.
~ Cannabis, The ECS & Female Reproduction ~
ECS & Related Mediators Across the
~ Menstrual Cycle ~
With & Without Endometrriosis
~ Menstrual Cycle ~
With & Without Endometrriosis
Endometriosis
According to the U.S. National Library of Medicine, Cannabinoids are an excellent choice for the treatment of endometriosis. Many women must submit their body to hormonal treatments that cause serious side effects like strokes and may even require surgical procedures such as hysterectomy.
The use of oils or cannabis infusions significantly improves the symptoms of this disease. How do they work? Cannabinoids bind to the endocannabinoid system, alleviating the main symptom of this disease: pain.
Your uterus will be happier!
The human body makes its own cannabinoids and anandamide is one of them. This substance helps women feel a sense of well-being and self-confidence during certain times of their menstrual cycle. (Ever wonder why most love chocolate, Anandamide AEA, the bliss molecule found in chocolate) In the ovulation phase, the uterus contains 100 percent more anandamide than the brain.
By consuming cannabis, the amount of this substance increases in the body and your uterus will return the help making you feel very comfortable with your body. Your reproductive health also will be improved.
Cannabinoids and modulators of the endocannabinoid system affect specific mechanisms that are critical to the establishment and development of endometriosis. The aim of this study was to measure the systemic levels of endocannabinoids and related mediators in women with and without endometriosis and to investigate whether such levels correlated with endometriosis-associated pain. Plasma and endometrial biopsies were obtained from women with a laparoscopic diagnosis of endometriosis (n = 27) and no endometrial pathology (n = 29). Plasma levels of endocannabinoids (N-arachidonoylethanolamine [AEA] and 2-arachidonoylglycerol [2-AG]) and related mediators (N-oleoylethanolamine [OEA] and N-palmitoylethanolamine [PEA]), messenger RNA expression of some of their receptors (cannabinoid receptor type 1 [CB1], CB2, transient receptor potential vanilloid type [TRPV1]), and the enzymes involved in the synthesis (N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D [NAPE-PLD]) and degradation (fatty acid amide hydrolase 1 [FAAH]) of AEA, OEA, and PEA were evaluated in endometrial stromal cells. The systemic levels of AEA, 2-AG, and OEA were elevated in endometriosis in the secretory phase compared to controls. The expression of CB1 was higher in secretory phase endometrial stromal cells of controls versus endometriosis. Similar expression levels of CB2, TRPV1, NAPE-PLD, and FAAH were detected in controls and endometriosis. Patients with moderate-to-severe dysmenorrhea and dyspareunia showed higher AEA and PEA levels than those with low-to-moderate pain symptoms, respectively. The association of increased circulating AEA and 2-AG with decreased local CB1 expression in endometriosis suggests a negative feedback loop regulation, which may impair the capability of these mediators to control pain. These preliminary data suggest that the pharmacological manipulation of the action or levels of these mediators may offer an alternative option for the management of endometriosis-associated pain.
The days before menstruation are very complicated for women and there is a scientific explanation for your bad mood. Anandamide, a cannabinoid produced by our body, is highly dependent on estrogen. The main cause of premenstrual syndrome is the decrease in estrogen that obviously results in low levels of anandamide.
According to the U.S. National Library of Medicine, Cannabinoids are an excellent choice for the treatment of endometriosis. Many women must submit their body to hormonal treatments that cause serious side effects like strokes and may even require surgical procedures such as hysterectomy.
The use of oils or cannabis infusions significantly improves the symptoms of this disease. How do they work? Cannabinoids bind to the endocannabinoid system, alleviating the main symptom of this disease: pain.
Your uterus will be happier!
The human body makes its own cannabinoids and anandamide is one of them. This substance helps women feel a sense of well-being and self-confidence during certain times of their menstrual cycle. (Ever wonder why most love chocolate, Anandamide AEA, the bliss molecule found in chocolate) In the ovulation phase, the uterus contains 100 percent more anandamide than the brain.
By consuming cannabis, the amount of this substance increases in the body and your uterus will return the help making you feel very comfortable with your body. Your reproductive health also will be improved.
Cannabinoids and modulators of the endocannabinoid system affect specific mechanisms that are critical to the establishment and development of endometriosis. The aim of this study was to measure the systemic levels of endocannabinoids and related mediators in women with and without endometriosis and to investigate whether such levels correlated with endometriosis-associated pain. Plasma and endometrial biopsies were obtained from women with a laparoscopic diagnosis of endometriosis (n = 27) and no endometrial pathology (n = 29). Plasma levels of endocannabinoids (N-arachidonoylethanolamine [AEA] and 2-arachidonoylglycerol [2-AG]) and related mediators (N-oleoylethanolamine [OEA] and N-palmitoylethanolamine [PEA]), messenger RNA expression of some of their receptors (cannabinoid receptor type 1 [CB1], CB2, transient receptor potential vanilloid type [TRPV1]), and the enzymes involved in the synthesis (N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D [NAPE-PLD]) and degradation (fatty acid amide hydrolase 1 [FAAH]) of AEA, OEA, and PEA were evaluated in endometrial stromal cells. The systemic levels of AEA, 2-AG, and OEA were elevated in endometriosis in the secretory phase compared to controls. The expression of CB1 was higher in secretory phase endometrial stromal cells of controls versus endometriosis. Similar expression levels of CB2, TRPV1, NAPE-PLD, and FAAH were detected in controls and endometriosis. Patients with moderate-to-severe dysmenorrhea and dyspareunia showed higher AEA and PEA levels than those with low-to-moderate pain symptoms, respectively. The association of increased circulating AEA and 2-AG with decreased local CB1 expression in endometriosis suggests a negative feedback loop regulation, which may impair the capability of these mediators to control pain. These preliminary data suggest that the pharmacological manipulation of the action or levels of these mediators may offer an alternative option for the management of endometriosis-associated pain.
The days before menstruation are very complicated for women and there is a scientific explanation for your bad mood. Anandamide, a cannabinoid produced by our body, is highly dependent on estrogen. The main cause of premenstrual syndrome is the decrease in estrogen that obviously results in low levels of anandamide.
Cannabiniods & Hormones ( Estrogen ),
ESC Regulation to create ( Harmony ) Homeostasis:
significance of endocannabinoid signalling in multiple reproductive events: Sertoli cell survival, spermatogenesis, placentation, fertilization, preimplantation embryo development, implantation and postimplantation embryonic growth. These studies have also opened new perspectives in clinical applications, pointing to the ECS as a new target for correcting infertility and for improving reproductive health in humans. Cannabis/cannabiniods Regulate and aid reproductive help through many forms and channels. One key function in which Cannabiniods/cannabis aids the reproductive health of humans/mammals is the Endocrine(hormone) system. In the first area of interaction, cannabinoids affect hypothalamic-pituitary control of reproduction in the brain. In normal sex hormone production, gonadotropin-releasing-hormone (GnRH) is synthesized by hypothalamic neurons and releases a string of interactions that ends in the up-regulation of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These intermediary sex hormones lead to direct synthesis of gonadal steroid hormones (such as estrogen, progesterone, etc.). Since multiple studies have confirmed that endocannabinoids modulate both GnRH and the cells in the reproductive region of the brain in general, this therefore means cannabinoids can cause changes in progesterone and estrogen. Specifically, an increase in cannabinoids and endocannabinoids decreases GnRH release, which ultimately also decreases progesterone. This holds up to general testing in which THC application reduces the circulating amount of both intermediary gonadal hormones, FSH and LH. Additionally, this holds across multiple species of mammals and even extends partially to amphibians!
According to WebMD, women can avoid discomfort, cravings that threaten their diet or the desire to kill someone thanks to consuming cannabis. After being medicated with cannabis, the woman will stabilize their estrogen levels and the terrible symptoms will disappear.
Say goodbye to menstrual pain!
Periods are often very painful for most women. Sometimes the pain is so severe that it disables women to work. Statistics show that at least two-thirds of all women suffer from menstrual pain. Over-the-counter medications manage to relieve pain, but you must need many doses to eliminate the discomfort.
A joint can be the solution to the problem in addition to providing an immediate and lasting effect. Cannabis-infused pelvic lotions are an alternative if work-related THC drug tests concerning you.
Activate your body and help you control your weight
The use of cannabis instead of alcohol is best for your weight. Every time you drink alcohol, your body must process it before digest what you have eaten, producing a store of fat. Smoking marijuana improves digestive function and is 100 percent calorie free.
The sativa strain is an ideal motivator because it is very energizing. Cannabis will help you to be more active, increase your creativity and have more fun. Many people experience creative blockages and this substance helps them regain their inspiration. If you are thinking of starting an exercise routine, cannabis can help you push your limitations and go outdoors to exercise.
They have found CB 1 & 2 Cannabiniod receptors have been found throughout the female reproductive system, right down to thr uterine tissue. the immune system sending cannabiniod receptors to places of need, injury or imbalance, the regulatory process over hormones and on and on check out the endocannabiniod system.
~ Cannabis The ECS & Female Fertility ~
One of the reasons why cannabis use during pregnancy is so controversial today is because the human body naturally produces its own cannabis-like compounds. ( Which ironically should make it less controversial ).
These compounds are called endocannabinoids, named after cannabis, and the endocannabiniod system is the bodies system that receives cannabis/cannabiniods, and governs/regulates all pathophysiological processes & More.
Endocannabinoids, however, were not discovered until the early 1990s.
In the few short decades since, researchers have found that these molecules play vital roles in reproduction.
As it turns out, they are critical for the development of an infant’s brain.
The endocannabinoid systems CB1 receptors are located primarily in the nervous system, but also found in reproductive tissues, connective tissues, adipose tissues, and other glands and organs.
The significance of endocannabinoid signalling in multiple reproductive events: Sertoli cell survival, spermatogenesis, placentation, fertilization, preimplantation embryo development, implantation and postimplantation embryonic growth.
The Endocannabiniod System has a important role to play in female fertiltity. CB 1 Receptos have been shown to be present in the ovaries, uterine, endometrium, and the developing Embryo (McPartland 1999); These cannabis-like molecules also determine whether or not a fertilized egg implants in the uterus.
There is an increasing recognition that the endocannabinoid system is the crucial cytokine-hormone system regulating early human pregnancy. The synchronous development of the fertilized embryo and the endometrium to ensure timely implantation has been shown to be one of the pivotal steps to successful implantation. This development is thought to be regulated by a finely balanced relationship between various components of the endocannabinoid system in the endometrium, the embryo and the Fallopian tube. In addition, this system has also been shown to be involved in the regulation of the development and maturation of the gametes prior to fertilization.
Anandamide: ( The bliss molecule, & THC are similar allowing THC to mimic Anandamide (Cannabiniods are Transporters, Enhancers & regenerators)
Anandamide (AEA) has been found to be present in the oviductal & follicular fluids ( fluids found in the fallopian tubes & the follicular antrum, the follicular antrum is the chamber in which ovarian follicles produce oocytes, or immature egg cells). CB 1 & 2 receptors have also been found in all stages of development of the oocyte itself. Mammalian sperm cells require a period of exposure to both male and female reproductive fluids in order to capacitate and able to fertilize a egg. The presence of Anandamide in the female reproductive fluids thus clearly assist in the capacitation of sperm cells on the journey to the fallopian tubes. As well as assisting in capacitating the sperm cell and facilitating its journey to the fallopian tubes where fertilization takes place, Anandamide and the CB 1 receptors have a crucial roll to play in ovulation, as well as in the implementation of the fertilized gamete in to the endometrium, or the lining of the womb. Specifically it has been shown that high levels of Anandamide are necessary for successful ovulation, and that the lower levels are advantageous during the implementation of the gamete into the uterine lining ( Talatine et al, 2009 ) the same study also indicates that Anandamide is high at 4, & 5 weeks of gestation and drop to much lower levels during the 6th week. The concentration of anandamide in the oocytes has been found to strongly correlate with the maturation and quality of the oocytes (Taylor et al, 2010), which in turn determine the success of ovulation. During early gestation, successful embryo passage through the oviduct and implantation into the uterus require critical enzymatic control of the endocannabinoid levels (Taylor et al., 2010). We have previously described that AEA induces apoptosis of decidual cells, effects dependent on CB1 activation, involving p38 phosphorylation and a drop in the mitochondrial membrane potential (Fonseca et al., 2009Fonseca et al., , 2013) It is not clear exactly by what mechanism anandamide works to control oocyte maturation; the fact that high levels of anandamide are necessary at this time would appear to contradict the findings of the big Pharma sponsored trials, that the use of THC can disrupt oogenesis and ovulation. The role of the endocannabinoid system in digestive health: cannabinoids are known to affect key physiological processes such as appetite and glucose metabolism, thereby potentially working to reduce the chances of obesity; obesity is strongly linked to reproductive health & Fertility, and the nutritional value of cannabis, especially raw, (Kief Raw/Raw Kief/Raw Greens) is off the charts with Nutritional value, all Amino Acids, plus 4 newly discovered, cannabis is a natural medicine that can aid in the mimicking, enhancement, protectant, neuroprotectant, of all the bodily systems/pathophysiological processes, the entire hormonal system especially Anandamide as its a almost a identical twin but with more medicinal & nutritional punch & the list goes on and on.
More on: Cannabis Nutrition (Raw Greens/cannabis)
More on: The Endocannabinoid System
More on: Cannabis and the Immune System
More on: Anandamide ( The bodies natural endocannabiniod hormone/neurotransmitter ).
THC in cannabis mimics this molecule your body already produces naturally.
Endocannabinoid system during development: emphasis on, developing unborn baby
The endocannabinoid system (ECS) including its receptors, endogenous ligands ("endocannabinoids"), synthesizing and degradating enzymes, and transporter molecules has been detected from the earliest embryonal stages and throughout pre- and postnatal development; endocannabinoids, notably 2-arachidonoylglycerol, are also present in maternal milk. During three developmental stages, (1) early embryonal, (2) prenatal brain development, and (3) postnatal suckling, the ECS plays an essential role for development and survival. During early gestation, successful embryonal passage through the oviduct and implantation into the uterus require critical enzymatic control of the endocannabinoids. During fetal life, endocannabinoids and the cannabinoid CB(1) receptor are important for brain development, regulating neural progenitor differentiation and guiding axonal migration and synaptogenesis. Postnatally, CB(1) receptor activation by 2-arachidonoylglycerol appears to play a critical role in the initiation of milk suckling in mouse pups, possibly by enabling innervation and/or activation of the tongue muscles. Perinatal manipulation of the ECS, by administering cannabinoids or by maternal marijuana consumption was a common practice in the past.
The endocannabinoid system (ECS) including its receptors, endogenous ligands ("endocannabinoids"), synthesizing and degradating enzymes, and transporter molecules has been detected from the earliest embryonal stages and throughout pre- and postnatal development; endocannabinoids, notably 2-arachidonoylglycerol, are also present in maternal milk. During three developmental stages, (1) early embryonal, (2) prenatal brain development, and (3) postnatal suckling, the ECS plays an essential role for development and survival. During early gestation, successful embryonal passage through the oviduct and implantation into the uterus require critical enzymatic control of the endocannabinoids. During fetal life, endocannabinoids and the cannabinoid CB(1) receptor are important for brain development, regulating neural progenitor differentiation and guiding axonal migration and synaptogenesis. Postnatally, CB(1) receptor activation by 2-arachidonoylglycerol appears to play a critical role in the initiation of milk suckling in mouse pups, possibly by enabling innervation and/or activation of the tongue muscles. Perinatal manipulation of the ECS, by administering cannabinoids or by maternal marijuana consumption was a common practice in the past.
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More on: Cannabis Nutrition (Raw Greens/cannabis)
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Cannabis Aiding Labour Pains
Cannabis preparations were used to treat labor pain
With all the methods that cannabis was utilized for it's own healing properties, never mind the ECS regulatory functions, some of the more recorded cases from the past is for the aid in nausea, Pain, migraines & Inflammation, ( history or history timeline ) all of which are a common ordeal throughout a pregnancy. Even today some of the most known and excepted functions of cannabis is the antiemtetic, anti-inflammatory & very good for pain reduction. With Cannabis possessing so many medicinal properties, ( Science & Nutrition ) all that Promoting good health and symptom relief, the Endocannabiniod system ECS regulating over such a range of pathophysiological processes, one could easily conclude That Cannabis would be a equal or a much better naturel pain reliever for aiding morning sickness, labour pains & even postpartum then ... side affects. Maybe human kind should do ourselves a favour and look closer with money Out of the equation!
- Check out the Medical Index section ie. autoimmune, neurological, cognitive disorders or POSTPARTUM DEPRESSION etc. Regardless of age, ( from the youngest to the oldest ) it is pretty clear cannabis possesses homeostasis regenerative properties
Development of Cannabis Babies
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Cannabinoids can mitigate the damage caused by perinatal hypoxic-ischemic event, a significant cause of developmental disorders in children (Godverbs)
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A significant cause of brain injury in the neonatal period is perinatal hypoxic-ischemic event—when the flow of oxygen and blood to the infant brain is interrupted due to asphyxia, often during childbirth. This devastating condition leads to the death of 15-20% of children diagnosed, and to severe neurological impairment—including epilepsy, cerebral palsy, motor dysfunction and hyperactivity—in a further 25%. The developing brain is far more susceptible to hypoxic-ischemic events than the adult brain, as it contains a high concentration of blood vessels and higher water content, and the potential for damage-inducing events such as haemorrhage is greater.
Immediately following hypoxic-ischemic brain injury, a set of specific cellular mechanisms including increased production of glutamate is set in motion, triggering cell damage and finally leading to excitotoxicity (a type of cell death caused by excessive glutamatergic signalling). cannabinoids, and their ability to inhibit glutamate release and other damaging compounds such as nitric oxide, make these
Cannabis compounds particularly attractive as a defence against hypoxic-ischemic progressive brain damage as it is known that glutamatergic excitotoxicity, nitric oxide toxicity and oxidative stress are all crucial factors in perinatal hypoxic-ischemic brain injury
cannabinoids provide a protective effect due to their role in glutamatergic signalling at the synapses (Ethan Hein). cannabis prevents the release of many damaging toxins. Furthermore, the antioxidant and modulatory properties of cannabinoids, with the neuroprotective neurogenesis ( the ability to grow new neurons ) & neuroplascity makes cannabis a beneficial nutrient, As well as modulating neural responses, cannabinoids have been shown to modulate vasodilation due to endothelial cell function and endothelin activity, regulate calcium homeostasis, and possess significant anti-excitotoxic and anti-inflammatory effects. There are also indications that certain anti-inflammatory treatments may actually improve recovery by promoting even more neurogenesis (growth of new neurons). Utilising the potential of the endocannabinoid system is therefore an important neuroprotective strategy for neonatal hypoxic-ischemic brain. During the neonatal period and for development stages right on through to adult hood.
There is abundant evidence indicating the effectiveness of phytocannabinoids, particularly CBD, in the management and mitigation of traumatic brain injury and ischemic stroke. Furthermore, our understanding of the role that the endogenous cannabinoids anandamide and 2-AG play in the modulation of inflammation and cerebral blood flow is growing, and our ability to synthesise targeted synthetic cannabinoids that can precisely mimic the actions of these endocannabinoids is improving with it.
Immediately following hypoxic-ischemic brain injury, a set of specific cellular mechanisms including increased production of glutamate is set in motion, triggering cell damage and finally leading to excitotoxicity (a type of cell death caused by excessive glutamatergic signalling). cannabinoids, and their ability to inhibit glutamate release and other damaging compounds such as nitric oxide, make these
Cannabis compounds particularly attractive as a defence against hypoxic-ischemic progressive brain damage as it is known that glutamatergic excitotoxicity, nitric oxide toxicity and oxidative stress are all crucial factors in perinatal hypoxic-ischemic brain injury
cannabinoids provide a protective effect due to their role in glutamatergic signalling at the synapses (Ethan Hein). cannabis prevents the release of many damaging toxins. Furthermore, the antioxidant and modulatory properties of cannabinoids, with the neuroprotective neurogenesis ( the ability to grow new neurons ) & neuroplascity makes cannabis a beneficial nutrient, As well as modulating neural responses, cannabinoids have been shown to modulate vasodilation due to endothelial cell function and endothelin activity, regulate calcium homeostasis, and possess significant anti-excitotoxic and anti-inflammatory effects. There are also indications that certain anti-inflammatory treatments may actually improve recovery by promoting even more neurogenesis (growth of new neurons). Utilising the potential of the endocannabinoid system is therefore an important neuroprotective strategy for neonatal hypoxic-ischemic brain. During the neonatal period and for development stages right on through to adult hood.
There is abundant evidence indicating the effectiveness of phytocannabinoids, particularly CBD, in the management and mitigation of traumatic brain injury and ischemic stroke. Furthermore, our understanding of the role that the endogenous cannabinoids anandamide and 2-AG play in the modulation of inflammation and cerebral blood flow is growing, and our ability to synthesise targeted synthetic cannabinoids that can precisely mimic the actions of these endocannabinoids is improving with it.
Although there is controversial studies, most opposing findings had inconsistencies, with in the study themselves and large amount of inconsistencies. with other well confirmed studies it is relatively easy to identify the studies where the investigators decide before hand that the study would not work. looking at more focused studies that over lapped eg. hormone studies, nutritional, Immune, cellular etc with reproduction studies, one can see obvious benefits.
a clinical study was completed with a, controlled environment on Jamaican mothers and their children3. This found that the mothers using cannabis had babies who were not only free of impairment, but deemed “superior”. They were more socially responsive, less irritable, and more alert and autonomically stable. However, these better scores were caused by higher educational attainment and financial independence among users.Nineteen of the 33 users reported that it relieved nausea and improved appetite; 15 said that it reduced fatigue. Participants also stated that they found relief from depression and feelings of desperation, associated with raising children in poverty.
Follow-up research4 conducted in California also found no developmental problems in the babies of mothers who used cannabis. In addition, three women previously thought to be sterile conceived; mothers were 8 times more likely to breastfeed for at least a year; and all gave birth naturally.
a clinical study was completed with a, controlled environment on Jamaican mothers and their children3. This found that the mothers using cannabis had babies who were not only free of impairment, but deemed “superior”. They were more socially responsive, less irritable, and more alert and autonomically stable. However, these better scores were caused by higher educational attainment and financial independence among users.Nineteen of the 33 users reported that it relieved nausea and improved appetite; 15 said that it reduced fatigue. Participants also stated that they found relief from depression and feelings of desperation, associated with raising children in poverty.
Follow-up research4 conducted in California also found no developmental problems in the babies of mothers who used cannabis. In addition, three women previously thought to be sterile conceived; mothers were 8 times more likely to breastfeed for at least a year; and all gave birth naturally.
Development of Cannabis Babies
Summary, Reproduction:
Cannabis is a essential Nutrient
The endocannabinoid system is being discovered in many more organs, where it plays multiple physiological roles, depending on the organ. In female reproduction, the endocannabinoid system is found in different creatures from sea urchin to humans. Its conserved expression spanning different animals. The wide variety of localization implicates that the endocannabinoid system (ECS) is responsible for several pathophysiological processes: modulation of ECS affects almost all human diseases such as obesity; diabetes and diabetic complications; neurodegenerative, inflammatory, cardiovascular, liver, gastrointestinal and skin diseases; pain and psychiatric disorders; cachexia and cancer amongst many others [8] The Nutritional value, with all the amino acids plus 4 more, and knowing how Deficient Endocannabiniods signaling causes multiple defects during pregnancy, all the benifical studies, the female reproductive system, accumulating evidence shows that CB-receptors, FAAH and ECs present in the ovary, oviduct, uterus, embryo and placenta play a key role in female reproduction, including oogenesis, preimplantation embryo development, oviductal embryo transport, implantation , decidualization and placentation, pregnancy maintenance and labor [5,9,10]. A recent study has shown that tightly regulated EC levels are critical for female reproductive success, as both silenced and elevated AEA levels result in unidirectional gene expression changes, causing impaired trophoblast migration ability [11]. ... a logical assumption is that cannabis is not ony medically beneficial but in the raw form especially is extremely nutritional. Although we are not Doctors We would recommend when utilizing product with activated Psychoactive THC, not to over indulge either as the fetus is in development & balance/moderation is always best. (As for Kief Raw/Raw kief, Raw greens, eat as much as you can. Psychoactive THC is inactive in the RAW form, and is Very Nutritional with all essential fatty acids.
Cannabis is a essential Nutrient
The endocannabinoid system is being discovered in many more organs, where it plays multiple physiological roles, depending on the organ. In female reproduction, the endocannabinoid system is found in different creatures from sea urchin to humans. Its conserved expression spanning different animals. The wide variety of localization implicates that the endocannabinoid system (ECS) is responsible for several pathophysiological processes: modulation of ECS affects almost all human diseases such as obesity; diabetes and diabetic complications; neurodegenerative, inflammatory, cardiovascular, liver, gastrointestinal and skin diseases; pain and psychiatric disorders; cachexia and cancer amongst many others [8] The Nutritional value, with all the amino acids plus 4 more, and knowing how Deficient Endocannabiniods signaling causes multiple defects during pregnancy, all the benifical studies, the female reproductive system, accumulating evidence shows that CB-receptors, FAAH and ECs present in the ovary, oviduct, uterus, embryo and placenta play a key role in female reproduction, including oogenesis, preimplantation embryo development, oviductal embryo transport, implantation , decidualization and placentation, pregnancy maintenance and labor [5,9,10]. A recent study has shown that tightly regulated EC levels are critical for female reproductive success, as both silenced and elevated AEA levels result in unidirectional gene expression changes, causing impaired trophoblast migration ability [11]. ... a logical assumption is that cannabis is not ony medically beneficial but in the raw form especially is extremely nutritional. Although we are not Doctors We would recommend when utilizing product with activated Psychoactive THC, not to over indulge either as the fetus is in development & balance/moderation is always best. (As for Kief Raw/Raw kief, Raw greens, eat as much as you can. Psychoactive THC is inactive in the RAW form, and is Very Nutritional with all essential fatty acids.
Postpartum Depression
Postpartum depression (PPD), also called postnatal depression, is a type of mood disorder associated with childbirth, which can affect both sexes.[1][3] Symptoms may include extreme sadness, low energy, anxiety, crying episodes, irritability, and changes in sleeping or eating patterns.[1] Onset is typically between one week and one month following childbirth.[1] PPD can also negatively affect the person's child.[2]
How Cannabis Aids:
known for many years, that depletion of the neurotransmitter serotonin in the brain leads to depression.
The anti-depressant and intoxicating effects of cannabis are due to its chemical similarity to natural substances in the brain known as "endo-cannabinoids. ... (cannabinoids increase activity in the neurons that produce serotonin). ...
The hippocampal NS/PCs are immunoreactive for CB1 cannabinoid receptors, indicating that cannabinoids act on CB1 receptors to regulate neurogenesis. ...
Postpartum Depression: For a complete clinical breakdown of postpartum & Cannabis, how it aids, effective methods to administer, picking the right related strain and more.
Postpartum depression (PPD), also called postnatal depression, is a type of mood disorder associated with childbirth, which can affect both sexes.[1][3] Symptoms may include extreme sadness, low energy, anxiety, crying episodes, irritability, and changes in sleeping or eating patterns.[1] Onset is typically between one week and one month following childbirth.[1] PPD can also negatively affect the person's child.[2]
How Cannabis Aids:
known for many years, that depletion of the neurotransmitter serotonin in the brain leads to depression.
The anti-depressant and intoxicating effects of cannabis are due to its chemical similarity to natural substances in the brain known as "endo-cannabinoids. ... (cannabinoids increase activity in the neurons that produce serotonin). ...
The hippocampal NS/PCs are immunoreactive for CB1 cannabinoid receptors, indicating that cannabinoids act on CB1 receptors to regulate neurogenesis. ...
Postpartum Depression: For a complete clinical breakdown of postpartum & Cannabis, how it aids, effective methods to administer, picking the right related strain and more.
A Collective Educated Opinion:
Cannabis is still the most-used illicit substance during pregnancy
Several cultures around the world still use cannabis and hemp products during pregnancy.
Yet, the herb has been outlawed in many countries, particularly Western societies.
Regardless, according to the World Health Organization, cannabis is the illicit substance most-used by pregnant women worldwide.
While you’ll be hardpressed to find medical professionals willing to suggest cannabis as a pregnancy remedy, many women still turn to the herb for relief from nausea and vomiting despite a lack of medical research on the
Several cultures around the world still use cannabis and hemp products during pregnancy.
Yet, the herb has been outlawed in many countries, particularly Western societies.
Regardless, according to the World Health Organization, cannabis is the illicit substance most-used by pregnant women worldwide.
While you’ll be hardpressed to find medical professionals willing to suggest cannabis as a pregnancy remedy, many women still turn to the herb for relief from nausea and vomiting despite a lack of medical research on the
Cannabis & Abortions
Cannabis was used in medicines used to induce abortions had cannabis in it: speculated for pain.
Historical evidence suggests that cannabis was used to facilitate labor and improve lactation in nursing mothers.
However, some societies also used the plant in concoctions intended to stimulate miscarriage or abortion.
Experts suggest that cannabis might have been included in these elixirs thanks to its pain-relieving qualities.
Historical evidence suggests that cannabis was used to facilitate labor and improve lactation in nursing mothers.
However, some societies also used the plant in concoctions intended to stimulate miscarriage or abortion.
Experts suggest that cannabis might have been included in these elixirs thanks to its pain-relieving qualities.
Menopause
Menopause, also known as the climacteric, is the time in most women's lives when menstrual periods stop permanently, and they are no longer able to bear children.[2][8] Menopause typically occurs between 49 and 52 years of age.[3] Medical professionals often define menopause as having occurred when a woman has not had any vaginal bleeding for a year.[4] It may also be defined by a decrease in hormone production by the ovaries.[9] In those who have had surgery to remove their uterus but still have ovaries, menopause may be viewed to have occurred at the time of the surgery or when their hormone levels fell.[9] Following the removal of the uterus, symptoms typically occur earlier, at an average of 45 years of age.[10]
Every woman experiences it with different symptoms and levels of severity. The most common symptoms of menopause range from emotional symptoms, like mood swings and anxiety, to physical symptoms such as hot flashes, insomnia and complications when having sex. Marijuana can help with a variety of symptoms caused by menopause, as well as help women who have problems with early onset menopause.
For a complete clinical breakdown of Menopause & Cannabis, how it aids, effective methods to administer, picking the right related strain and more Check out Medical Index or Menopause
Estrogen Levels & the Endocannabinoid System
Endocannabinoid levels are closely linked to estrogen levels. Endocannabinoid levels, like estrogen levels, are highest during ovulation. Estrogen helps regulate the fatty acid amide hydrolase (FAAH), which breaks down the naturally occurring endocannabinoid anandamide—also known as the bliss molecule.
When there’s an insufficient amount of estrogen in the system, endocannabinoids will begin to be broken down by the larger presence of FAAH. The body’s naturally occurring endocannabinoids can be supplemented with cannabinoids from marijuana to reduce the effects of the breakdown of naturally occurring endocannabinoids and other symptoms related to endocannabinoid deficiency.
Various medical conditions can cause menopause to come on early, which can sometimes cause even stronger symptoms. Clinical endocannabinoid deficiency is believed to be a cause of early onset menopause, as well as medical conditions such as breast cancer. Estrogen replacement therapy, or ERT, is a common treatment for many menopausal and post-menopausal women who experience extreme symptoms, but it’s not available or recommended for everyone.
Using Cannabis Instead of Hormone Replacement Therapy for Menopause
Cannabis can be a great alternative for women who can’t undergo ERT due to having had conditions such as ovarian cancer or heart disease. ERT is often administered to help prevent adverse problems from menopause such as bone loss. The cannabinoids CBD, CBG, CBC, and TCHV have been found to help stimulate bone growth and help prevent the onset of osteoporosis after menopause. Supplementing endocannabinoids from cannabis can help stimulate the body and delay some of the effects of early menopause.
Cannabis can also work to regulate the body after menopause. Less estrogen is produced in the body post-menopause, and in turn the body produces fewer natural endocannabinoids. The decrease in endocannabinoid production can cause a variety of problems—for example, an impaired ability to respond to stress. Cannabis can help supplement the body’s natural endocannabinoids and decrease the symptoms associated with lower levels of estrogen and endocannabinoids.
Cannabis for the Relief of Symptoms Associated With Menopause
Cannabis can also help fight many of the most common symptoms associated with menopause. It can help reduce anxiety and stress, which can be a common part of mood swings associated with menopause. CBD-heavy strains can be particularly helpful for women who experience anxiety with menopause.
Cannabis can also help ease insomnia. THC-heavy indica strains are known to be the best at promoting sleep. In addition, women may find that taking marijuana can help ease sexual discomfort that often comes on during menopause. Sex can be uncomfortable due to a decrease in sexual desire or other related issues, such as increased vaginal dryness.
The bottom line: Marijuana can help with a variety of menopause symptoms that women face when going through menopause.
Menopause, also known as the climacteric, is the time in most women's lives when menstrual periods stop permanently, and they are no longer able to bear children.[2][8] Menopause typically occurs between 49 and 52 years of age.[3] Medical professionals often define menopause as having occurred when a woman has not had any vaginal bleeding for a year.[4] It may also be defined by a decrease in hormone production by the ovaries.[9] In those who have had surgery to remove their uterus but still have ovaries, menopause may be viewed to have occurred at the time of the surgery or when their hormone levels fell.[9] Following the removal of the uterus, symptoms typically occur earlier, at an average of 45 years of age.[10]
Every woman experiences it with different symptoms and levels of severity. The most common symptoms of menopause range from emotional symptoms, like mood swings and anxiety, to physical symptoms such as hot flashes, insomnia and complications when having sex. Marijuana can help with a variety of symptoms caused by menopause, as well as help women who have problems with early onset menopause.
For a complete clinical breakdown of Menopause & Cannabis, how it aids, effective methods to administer, picking the right related strain and more Check out Medical Index or Menopause
Estrogen Levels & the Endocannabinoid System
Endocannabinoid levels are closely linked to estrogen levels. Endocannabinoid levels, like estrogen levels, are highest during ovulation. Estrogen helps regulate the fatty acid amide hydrolase (FAAH), which breaks down the naturally occurring endocannabinoid anandamide—also known as the bliss molecule.
When there’s an insufficient amount of estrogen in the system, endocannabinoids will begin to be broken down by the larger presence of FAAH. The body’s naturally occurring endocannabinoids can be supplemented with cannabinoids from marijuana to reduce the effects of the breakdown of naturally occurring endocannabinoids and other symptoms related to endocannabinoid deficiency.
Various medical conditions can cause menopause to come on early, which can sometimes cause even stronger symptoms. Clinical endocannabinoid deficiency is believed to be a cause of early onset menopause, as well as medical conditions such as breast cancer. Estrogen replacement therapy, or ERT, is a common treatment for many menopausal and post-menopausal women who experience extreme symptoms, but it’s not available or recommended for everyone.
Using Cannabis Instead of Hormone Replacement Therapy for Menopause
Cannabis can be a great alternative for women who can’t undergo ERT due to having had conditions such as ovarian cancer or heart disease. ERT is often administered to help prevent adverse problems from menopause such as bone loss. The cannabinoids CBD, CBG, CBC, and TCHV have been found to help stimulate bone growth and help prevent the onset of osteoporosis after menopause. Supplementing endocannabinoids from cannabis can help stimulate the body and delay some of the effects of early menopause.
Cannabis can also work to regulate the body after menopause. Less estrogen is produced in the body post-menopause, and in turn the body produces fewer natural endocannabinoids. The decrease in endocannabinoid production can cause a variety of problems—for example, an impaired ability to respond to stress. Cannabis can help supplement the body’s natural endocannabinoids and decrease the symptoms associated with lower levels of estrogen and endocannabinoids.
Cannabis for the Relief of Symptoms Associated With Menopause
Cannabis can also help fight many of the most common symptoms associated with menopause. It can help reduce anxiety and stress, which can be a common part of mood swings associated with menopause. CBD-heavy strains can be particularly helpful for women who experience anxiety with menopause.
Cannabis can also help ease insomnia. THC-heavy indica strains are known to be the best at promoting sleep. In addition, women may find that taking marijuana can help ease sexual discomfort that often comes on during menopause. Sex can be uncomfortable due to a decrease in sexual desire or other related issues, such as increased vaginal dryness.
The bottom line: Marijuana can help with a variety of menopause symptoms that women face when going through menopause.
Lies & Propaganda
Studies on prenatal cannabis consumption are inconsistent
Cannabis today is significantly stronger than it was when our ancestors began cultivating the plant.
While it was once used frequently as a pregnancy and labor aid, medical professionals today have concerns about the healing herb.
Thus far, there is no conclusive evidence that cannabis causes negative birth outcomes.
However, some research has shown a correlation between prenatal cannabis use and undesirable effects. These include:
Demographics like socioeconomic status and other factors like alcohol and tobacco consumption can contribute to unfavorable results, making it particularly difficult to tease out whether cannabis alone or a combination of factors created these outcomes.
Cannabis today is significantly stronger than it was when our ancestors began cultivating the plant.
While it was once used frequently as a pregnancy and labor aid, medical professionals today have concerns about the healing herb.
Thus far, there is no conclusive evidence that cannabis causes negative birth outcomes.
However, some research has shown a correlation between prenatal cannabis use and undesirable effects. These include:
- Low birthweight
- Shorter duration of pregnancy
- Poorer school outcomes
- Cognitive changes
- Longer time in the intensive care unit
Demographics like socioeconomic status and other factors like alcohol and tobacco consumption can contribute to unfavorable results, making it particularly difficult to tease out whether cannabis alone or a combination of factors created these outcomes.
Clinical Studies
Study - 1999 - Marijuana & Medicine: The Endocrine effects of Cannabis
- And/or check out the patent & Clinical Study pages:
For More Clinical Studies Check Out,
- And/or check out the patent & Clinical Study pages:
For More Clinical Studies Check Out,
- List of Cannabis Studies
- List of Endocannabiniods & Cannabis Studies
- List of THC & Cannabis Studies
- List of CBD & Cannabis Studies
At the September 2013 IACM meeting in Cologne, Raphael Mechoulam recounted a hypothesis published by Pal Pacher and George Kunos in FEBS (The Journal of the Federation of European Biochemical Societies): “modulating endocannabinoid activity may have therapeutic potential in almost all diseases affecting humans.”
