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Changing Medicine Together
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~ OCD ~
How cannabis aids
AM251 blocked CBD effects in the marble burying model [14], whereas 5-HT1A-receptor antagonism was ineffective. This result corroborates the proposal that anxiety and OCD models engage distinct brain mechanisms, with the marble burying behaviour being related to repetitive behaviours instead of anxiety [61].
How facilitation of eCB-mediated neurotransmission decreases repetitive behaviour is research in progress, but as of yet, we can say with reasonable confidence through several observatory studies that decrease of neurotransmission causing behavioural repetition may involve attenuation of glutamate-mediated neurotransmission. eCBs can reduce the release of several neurotransmitters, including glutamate [62], a major neurotransmitter of the cortico-striato-thalamo-cortical circuitry that has been implicated in the pathophysiology of OCD [63]. Anti-glutamatergic drugs such as riluzole and memantine decrease marble burying behaviour [64,65] and are proposed to be clinically useful for OCD treatment [66,67].
How facilitation of eCB-mediated neurotransmission decreases repetitive behaviour is research in progress, but as of yet, we can say with reasonable confidence through several observatory studies that decrease of neurotransmission causing behavioural repetition may involve attenuation of glutamate-mediated neurotransmission. eCBs can reduce the release of several neurotransmitters, including glutamate [62], a major neurotransmitter of the cortico-striato-thalamo-cortical circuitry that has been implicated in the pathophysiology of OCD [63]. Anti-glutamatergic drugs such as riluzole and memantine decrease marble burying behaviour [64,65] and are proposed to be clinically useful for OCD treatment [66,67].